Qinghai Province is located in the northwest part of China, is part of Qinghai-Tibet Plateau, its special location, abnormal climate, is the frequent occurrence of earthquake disaster area. Under the background of global climate change, earthquake disaster research in Qinghai province is of great significance for ecological protection and disaster prevention. In this paper, the data of earthquake disaster with MS ≥ 5 in Qinghai Province from 1960 to 2022 are collected statistically, and the risk grade distribution map of earthquake disaster is made by using GIS technology with the county and city as the unit. The spatial and temporal distribution law of earthquake disaster is illustrated from the distribution of earthquakes over the years and the annual occurrence frequency. The results show that the earthquake disasters in Qinghai Province are mainly concentrated in the northwest and southwest areas, the central and northern areas are also relatively high distribution, among which Geermu city and Yushu City are more affected. In terms of time, earthquake disasters occurred frequently from 1990 to 2010, and the frequency of disasters decreased slightly from 2010 to 2020, but in the past two years, the geological activity is more frequent, and the disaster incidence is high.