The temporal sequence of spontaneous repair of osteochondral defects in the knees of rabbits is dependent on the geometry of the defect

Lietman, Steven A.; Miyamoto, S.; Brown, Patrick; Inoue, N.; Reddi, A. Hari

doi:10.1302/0301-620x.84b4.0840600

Cited by 26 publications

(12 citation statements)

References 18 publications

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“…It has been shown that spontaneous healing of osteochondral defects is dependent on defect size, 13 depth, 14 geometry 15 and age 16 of the individual, but little is known about the influence of defect location on the natural healing response of osteochondral defects in the knee joint.…”

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confidence: 99%

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

et al. 2009

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Various animal models for experimental osteochondral defect healing have been used in orthopaedic research. Two main defect locations were chosen: the patellar groove or the central part of the medial femoral condyles (MFC). To date, it is not clear whether both locations display similar patterns in critical size osteochondral defect healing. We retrospectively analysed both locations in our minipig model hypothesizing that they show similar healing pattern. Thirty-five defects were analysed after three or 12 months. Osteochondral defects were 10 mm deep and 6.3 mm (MFC, n ¼ 19) in diameter or 8 mm and 5.4 mm, respectively (trochlear groove [TG], n ¼ 16). Semi-quantitative histological scoring and histomorphological evaluation were carried out. Both defect locations showed fillings of fibrous and fibrocartilage-like repair tissue. The osseous defect was closed by endochondral bone formation in the MFC. Semi-quantitative scoring did not show differences, whereas qualitative histomorphological analysis more frequently showed cartilaginous repair tissue in MFC defects. There was more frequent subchondral bone cyst formation in MFC location (P ¼ 0.05), TG defects resulted in lower postoperative pain. Both defect localizations are suitable for studies on osteochondral healing. Since regenerating with less hyaline-like repair tissue and less subchondral cyst formation, TG is more favourable for experimental osteochondral defect healing in this model.

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confidence: 99%

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

et al. 2009

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“…In general, cartilage repair does not represent a large defect and, in rabbits, spontaneous repair has been noted, depending on the geometry of the lesion [26].…”

Section: Resultsmentioning

confidence: 99%

Adhesion reduction after knee surgery in a rabbit model by Hyaloglide®, a hyaluronan derivative gel

et al. 2005

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A randomized controlled experimental trial was performed in a rabbit model of surgical adhesions to investigate the anti-adhesive effects of Hyaloglide@, a highly viscous hyaluronan derivative absorbable gel after knee surgery. Twenty New Zealand white rabbits were prepared and randomly divided into two groups of 10 animals each. An intra-articular fibro-adhesive scar was created in the right knee joint of the hind paw of each rabbit using a standardized surgical procedure, and Hyaloglide@ was administered into the joint cavity of the knee at the end of intervention in the animals belonging to the treatment group. No anti-adhesive treatment was applied in the control group. Additionally, immobilization using a Kirschner wire was applied in order to increase the risk of adhesions. Six weeks after surgery the animals were euthanized and after removal of the immobilization system, adhesions were evaluated both macroscopically and histologically. Results of gross observations using a specific adhesion scoring system showed a significant reduction (p < 0.01) of both incidence and severity of adhesions in the hyaluronan-treated group compared to the control group. Histologically, adhesions in the treated group were thinner with less collagenic fibers.In conclusion, Hyaloglide@ may be considered as a promising absorbable barrier for prevention of post-operative fibrotic adhesions after knee surgery.

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“…Another animal in the Hyaloglide@ group showed neo-formation of cartilage. In general, cartilage repair does not represent a large defect and, in rabbits, spontaneous repair has been noted, depending on the geometry of the lesion [26].…”

Section: Resultsmentioning

confidence: 99%

Adhesion reduction after knee surgery in a rabbit model by Hyaloglide, a hyaluronan derivative gel

Brunelli

LONGINOTTI

Bertazzo

et al. 2005

Journal of Orthopaedic Research

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A randomized controlled experimental trial was performed in a rabbit model of surgical adhesions to investigate the anti-adhesive effects of Hyaloglide, a highly viscous hyaluronan derivative absorbable gel after knee surgery. Twenty New Zealand white rabbits were prepared and randomly divided into two groups of 10 animals each. An intra-articular fibro-adhesive scar was created in the right knee joint of the hind paw of each rabbit using a standardized surgical procedure, and Hyaloglide was administered into the joint cavity of the knee at the end of intervention in the animals belonging to the treatment group. No anti-adhesive treatment was applied in the control group. Additionally, immobilization using a Kirschner wire was applied in order to increase the risk of adhesions. Six weeks after surgery the animals were euthanized and after removal of the immobilization system, adhesions were evaluated both macroscopically and histologically. Results of gross observations using a specific adhesion scoring system showed a significant reduction (p<0.01) of both incidence and severity of adhesions in the hyaluronan-treated group compared to the control group. Histologically, adhesions in the treated group were thinner with less collagenic fibers. In conclusion, Hyaloglide may be considered as a promising absorbable barrier for prevention of post-operative fibrotic adhesions after knee surgery.

show abstract

The temporal sequence of spontaneous repair of osteochondral defects in the knees of rabbits is dependent on the geometry of the defect

Cited by 26 publications

References 18 publications

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

Adhesion reduction after knee surgery in a rabbit model by Hyaloglide®, a hyaluronan derivative gel

Adhesion reduction after knee surgery in a rabbit model by Hyaloglide, a hyaluronan derivative gel

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