The temporal turning window for rat behavioral phenotypes by rotenone

Abstract

Availability of animal models of human neuronal disease has been contributing to reveal their etiology. Particularly, dopaminergic neurodegeneration has been shown by exposure of rats to chemicals, such as rotenone, corresponding to the rat models of attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. A single chemical of rotenone causes two behavioral phenotypes, both of which are completely opposite; hyperactivity or hypoactivity. They were created by different timing of chemical exposure, neonatal periods or adulthood, suggesting that there would be a temporal turning point of two behavioral phenotypes. Therefore, we examine a turning point of these behavioral phenotypes by measuring the spontaneous motor activity of rotenone models. We estimate the turning window of both behavioral phenotypes would be around between three weeks and four weeks of age in the rat dopaminergic neurodegeneration. Gene set enrichment analysis extracts a cytokine network in both rat models.