The tenascin family of ECM glycoproteins: Structure, function, and regulation during embryonic development and tissue remodeling

Jones, Frederick S.; Jones, Peter

doi:10.1002/(sici)1097-0177(200006)218:2<235::aid-dvdy2>3.0.co;2-g

Cited by 581 publications

(238 citation statements)

References 271 publications

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“…Taking our results into consideration, they suggest that the connective tissue of the polyps presents modifications of the extracellular matrix regarding organization as well as composition. The extracellular matrix is an important substrate for tissue morphogenesis, imparting instructive signals for cell proliferation, migration, and differentiation [9,22,25]. Therefore, it would be reasonable to hypothesize that alteration of the extracellular matrix may be an important event in the pathogenesis of the tonsillar polyps.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical study of stromal and vascular components of tonsillar polyps: high endothelial venules as participants of the polyp’s lymphoid tissue

et al. 2011

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Tonsillar polyps are nonneoplastic lesions usually composed of variable amounts of lymphoid and vascular and connective tissues. All of them are generally assumed to be hamartomatous proliferations, but the profile of vascular and connective components has yet to be explored. The vascular system of the tonsils is complex and includes highly specialized structures (i.e., high endothelial venules (HEVs)) involved in lymphocyte homing into lymphoid tissues. In 14 tonsillar polyps and 26 control tonsils, an immunohistochemical study was performed using CD34 (blood vessels and HEVs), MECA-79 (HEVs), D2-40 (lymphatic vessels), Ki-67, collagens I and III, fibronectin, and tenascin-C. The polyps showed increased total lymphatic area, whereas the number of blood vessels and lymphatics and the blood vascular area did not differ significantly from those of control tonsils. Rare Ki-67+ endothelial cells were found. In the polyps, we detected, possibly for the first time, HEVs amid lymphoid tissue, and that the amount of the latter correlated positively with HEV density. The polyps also presented lesser amounts of fibronectin and collagens I and III than in normal tonsils, which were distributed in a disorganized fashion. Tenascin-C expression was uncommon in the polyps and control tonsils. Tonsillar polyps are composed of disorganized connective tissue and lymphatic channels which can be considered hamartomatous proliferations. However, the lymphoid component is possibly reactive due to its relationship with the HEVs. The highly differentiated phenotype of the HEVs and their complex biology are not in agreement with what would be expected for a component of hamartomatous nature.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical study of stromal and vascular components of tonsillar polyps: high endothelial venules as participants of the polyp’s lymphoid tissue

et al. 2011

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“…In particular, tenascin-C (TN-C), a multifunctional ECM glycoprotein, is highly up-regulated in many different cancers such as glioma, breast cancer, ovarian cancer and prostate cancer ( [3] and references therein). Under normal circumstance, TN-C is only expressed during the early stages of development and is absent or much reduced in developed tissues [4]. Since the reappearance of TN-C is closely associated with pathological conditions like carcinogenesis and usually indicative of poor prognosis [3], it makes an attractive target for ligand-targeted therapeutic strategies, similar to other ECM-associated targets such as integrins and ED-B fibronectin [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells

Shao

Hou

et al. 2007

Cell. Mol. Life Sci.

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Tenascin-C is an extracellular matrix glycoprotein, whose expression is highly restricted in normal adult tissues, but markedly up-regulated in a range of tumors, and therefore serves as a potential receptor for targeted anticancer drug or gene delivery. We describe here a liposomal carrier system in which the targeting ligand is sulfatide. Experiments with tenascin-C-expressing glioma cells demonstrated that binding of liposomes to the extracellular matrix relied essentially on the sulfatide-tenascin-C interaction. Following binding to the extracellular matrix, the sulfatide-containing liposomes were internalized via both caveolae/lipid raft- and clathrin-dependent pathways, which would ensure direct cytoplasmic release of the cargoes carried in the liposomes. Such natural lipid-guided intracellular delivery targeting at the extracellular matrix glycoproteins of tumor cells thus opens a new direction for development of more effective anticancer chemotherapeutics in future.

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“…In the central nervous system, various extracellular matrix components have been identified which are strongly expressed during development, and in most areas of the brain, down-regulated during maturation. Examples of such components are tenascin-C, an oligomeric glycoprotein [1], neurocan, a chondroitin sulfate proteoglycan [2] and also the polysaccharide hyaluronan [3]. Tenascin-C is known to be associated with a large variety of morphogenic events in different tissues, and its expression increases whenever tissue regeneration or remodeling occur, as in healing wounds and during oncogenesis [4].…”

Section: Introductionmentioning

confidence: 99%

Extracellular matrix components associated with remodeling processes in brain

Rauch

2004

CMLS, Cell. Mol. Life Sci.

183

146

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In the central nervous system, various extracellular matrix components have been identified which are strongly expressed during development and in most areas of the brain down-regulated during maturation. Examples are tenascin-C, neurocan and hyaluronan. While tenascin-C is well known to be associated with morphogenic events and the active contribution of hyaluronan to various physiological processes is increasingly acknowledged, neurocan belongs to a class of molecules thought to be generally more associated with barrier functions: chondroitin sulfate CMLS Cellular and Molecular Life Sciencesproteoglycans. Consideration of these and related molecules and their processing in the context of the general organization of the brain extracellular matrix, their changes during brain maturation and their implication in different types of remodeling processes in adult brain, like normal and pathological synaptic plasticity, inflammatory and dementia-associated diseases and gliomas, may indicate that components of the extracellular matrix could provide valuable early information about the pathological state of the brain.

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The tenascin family of ECM glycoproteins: Structure, function, and regulation during embryonic development and tissue remodeling

Cited by 581 publications

References 271 publications

Immunohistochemical study of stromal and vascular components of tonsillar polyps: high endothelial venules as participants of the polyp’s lymphoid tissue

Immunohistochemical study of stromal and vascular components of tonsillar polyps: high endothelial venules as participants of the polyp’s lymphoid tissue

Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells

Extracellular matrix components associated with remodeling processes in brain

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