The Tensile Strength of Tablets of Binary Mixtures Lubricated with Magnesium Stearate

Sheikh-Salem, Mutaz; Alkaysi, H. N.; Fell, John T.

doi:10.3109/03639048809151909

Cited by 8 publications

(6 citation statements)

References 1 publication

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“…MgSt usually decreases or has no effect on the tensile strength of the tablets [ 49 , 50 , 51 , 52 ]. However, our results showed that this excipient increased the tensile strength of the tablets.…”

Section: Resultsmentioning

confidence: 99%

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

et al. 2020

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Background: Intestinal nematode infections are usually treated with benzimidazole drugs, but the emergence of resistance to these drugs has led to an increasing demand of new anthelmintic strategies. A new microemulsion formulation (ME) consisting of an Artemisia absinthium extract with proven nematocidal efficacy was previously developed. The aim of our study is to implement a D-optimal mixture design methodology to increase the amount of a silica material (loaded with this ME) in a tablet formulation, considering its tensile strength and disintegration time. Methods: 16 experiments or combinations of the 6 tablet components (loaded silica, microcrystalline cellulose, polyvinylpyrrolidone, croscarmellose, Syloid® 244 FP and magnesium stearate) were assessed. Tensile strength and disintegration time models were developed, and an optimization process was carried out. Results: Tensile strength was improved by increasing the polyvinylpyrrolidone content, while croscarmellose decreased the disintegration time. The optimized powder mixture contains 49.7% w/w of the loaded silica material. A compression force of 12 kN was applied to the powder mixture to form tablets with a tensile strength of 2.0 MPa and a disintegration time of 3.8 min. Conclusions: Our results show that D-optimal mixture designs provide a promising approach to formulate liquid-loaded silica materials.

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Section: Resultsmentioning

confidence: 99%

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

et al. 2020

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“…The mixtures of dicalcium phosphate dihydrate and phenacetin lead to the formation of tablet with higher tensile strength than the tablets of their individual materials [11]. However, the addition of some other materials produced tablets of lower strength than the tablets of individual materials [12].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Compaction Properties of Binary and Bilayer Tablets of Direct Compression Excipients

Amin¹,

Albawani²,

Amjad³

2012

Trop. J. Pharm Res

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“…It has been reported in some studies that the hardness of tablets prepared from a mixture of two materials can be predicted from the hardness of tablets prepared from each of these materials, as a linear relationship can be drawn for the composition of the mixture. 43,44 Tablet hardness has been shown to exceed the hardness of tablets prepared from individual materials, 45,46 whilst in other studies it has been lowered compared to that of the individual components. 47,44 F1 and F2 formulations using calcium carbonate were pressed successfully, and the good bonding capacity under compression of calcium carbonate 40 and its role as a filler in pharmaceutical formulations 36 probably justifies this.…”

Section: Tablet Friability Hardness Weight Uniformity and Drug Contmentioning

confidence: 93%

“…43,44 Tablet hardness has been shown to exceed the hardness of tablets prepared from individual materials, 45,46 whilst in other studies it has been lowered compared to that of the individual components. 47,44 F1 and F2 formulations using calcium carbonate were pressed successfully, and the good bonding capacity under compression of calcium carbonate 40 and its role as a filler in pharmaceutical formulations 36 probably justifies this. However, although pressing sodium carbonate alone shows good bonding capacity, 48 tablets containing sodium carbonate at 10%…”

Section: Tablet Friability Hardness Weight Uniformity and Drug Contmentioning

confidence: 93%

Influence of calcium carbonate and sodium carbonate gassing agents on pentoxifylline floating tablets properties

2017

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Purpose: this study was to design and evaluate effervescent floating tablets with sustained release behaviour. Pentoxifylline is a water-soluble model drug with a short half-life, consequently developing sustained release preparations would be beneficial. Methods: a binary (1:1) mixture of sodium alginate and hydroxyethyl cellulose containing pentoxifylline, with either 10% or 20% calcium carbonate or sodium carbonate, was used to prepare floating tablets. Results: tablets floated on the surface of the dissolution medium, showed an adequate floating lag time, and floated for more than 12 hours. Tablets manufactured from granules with 20%(w/w) calcium carbonate were promising with respect to their floating lag time (~7min), floating duration (>24 hours), sustained drug release rate, and swelling ability. An in vivo study of these promising tablets and a reference solution of pentoxifylline were investigated following oral administration of 5.75±0.15mg in rats. Compared with the reference solution, the pharmacokinetic parameters changed significantly (p<0.05); the Cmax of the tablets was decreased (945.32ng/ml versus 2552.30ng/ml for the solution), while the Tmax and t1/2 were prolonged. Conclusion: the study shows that a binary mixture of hydroxyethyl cellulose and sodium alginate, together with 20%(w/w) calcium carbonate, offers an exciting opportunity to develop sustained release pentoxifylline preparations.

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The Tensile Strength of Tablets of Binary Mixtures Lubricated with Magnesium Stearate

Cited by 8 publications

References 1 publication

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

A Comparative Study of the Compaction Properties of Binary and Bilayer Tablets of Direct Compression Excipients

Influence of calcium carbonate and sodium carbonate gassing agents on pentoxifylline floating tablets properties

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