The teratologic effects of thalidomide in Himalayan rabbits

Lehmann, Horst; Niggeschulze, A.

doi:10.1016/0041-008x(71)90329-2

Cited by 17 publications

(2 citation statements)

References 9 publications

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“…Himalayan rabbits react as well to the oral administration of Thalidomide as do other rabbit strains [4]. Under our laboratory conditions, the conception rate of the breeding group not mated experimentally has been slightly lower from July through October, possibly due to the chance in a small number of animals.…”

Section: Discussionmentioning

confidence: 85%

Identification of a Substrain of Himalayan Rabbits Produced in Japan

Matsuo

Kazuta

Kast

1981

Experimental Animals

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Section: Discussionmentioning

confidence: 85%

Identification of a Substrain of Himalayan Rabbits Produced in Japan

Matsuo

Kazuta

Kast

1981

Experimental Animals

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“…51 The relationship between dose and response was clearly shown in Himalayan rabbits exposed to thalidomide, where the incidence of defects in leg bones, malformation of the digits and sternal synostosis were all dose-related. 52 The degradation of a transcription factor called SALL4 has been implicated in the harm caused by thalidomide, which resembles the Duane Radial Ray Syndrome that results from loss-of-function mutations in the gene coding for SALL4. 53 There are mutations in the zinc-finger domain of murine SALL4 that protect it from the action of thalidomide, and explain why mice are not susceptible to thalidomide embryopathy.…”

Section: Physiological Changesmentioning

confidence: 99%

Susceptibility to adverse drug reactions

Ferner

Aronson

2019

Brit J Clinical Pharma

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The pharmacological effects of a drug depend on its concentration at the site of action, and therefore on the concentration in blood and on the dose. The relationship between the concentration or dose and the corresponding effect can usually be represented mathematically as a rectangular hyperbola; when effect is plotted against log concentration or log dose, the curve is sigmoidal.Inevitably, the effect size and the doses causing benefit and harm will differ among individuals, since they are biological phenomena: some individuals are more likely than others to suffer harm at any given dose. Some harmful effects can occur at much lower doses than those used in therapeutics; that is, the log dose–response curve for harm lies far to the left of the log dose–response curve for benefit. Those who suffer such reactions are hypersusceptible. When the dose–response curves for harm and therapeutic effect are in the same range, dose cannot separate the harmful effects from the therapeutic effects, and adverse reactions are collateral. Toxic effects occur when harmful doses are above the doses needed for benefit.In this review we consider factors that influence a subject's susceptibility to adverse drug reactions. Determinants of susceptibility include Immunological, Genetic, demographic (Age and Sex), Physiological and Exogenous factors (drug–drug interactions, for example), and Diseases and disorders such as renal failure, giving the mnemonic I GASPED. Some susceptibility factors are discrete (for example, all‐or‐none) and some are continuous; susceptibility can therefore be discrete or continuous; and the factors can interact to determine a person's overall susceptibility to harm.

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Adverse Effects in Humans and Animals of Prenatal Exposure to Selected Therapeutic Drugs and Estimation of Embryo-Fetal Sensitivity of Animals for Human Risk Assessment

Khera

1984

Issues and Reviews in Teratology

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The teratologic effects of thalidomide in Himalayan rabbits

Cited by 17 publications

References 9 publications

Identification of a Substrain of Himalayan Rabbits Produced in Japan

Identification of a Substrain of Himalayan Rabbits Produced in Japan

Susceptibility to adverse drug reactions

Adverse Effects in Humans and Animals of Prenatal Exposure to Selected Therapeutic Drugs and Estimation of Embryo-Fetal Sensitivity of Animals for Human Risk Assessment

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