The testosterone mimetic properties of icariin

Zhang, Zhen-bao; Yang, Qingtao

doi:10.1111/j.1745-7262.2006.00197.x

Cited by 79 publications

(73 citation statements)

References 15 publications

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“…5 In addition to its erotogenic role, icariin has demonstrated testosterone-mimetic properties. 6 Icariin has been shown to increase the intracavernous pressure in rats, which could be abolished nitric oxide synthase (NOS) and guanylate cyclase inhibitors. 7 Furthermore, icariin has successfully ameliorated both castration-related and arteriogenic impairment of erectile function and has reduced penile neuron NOS concentration in a rodent model.…”

Section: Introductionmentioning

confidence: 99%

Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO–cGMP pathway

Zhang¹,

Li²,

Liu³

et al. 2012

Asian J Androl

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Erectile dysfunction (ED) is a major complication of diabetes mellitus. Icariin has been shown to enhance erectile function through its bioactive form, icarisid II. This study investigates the effects of icarisid II on diabetic rats with ED and its potential mechanism via the assessment of advanced glycosylation end products (AGEs), autophagy, mTOR and the NO-cGMP pathway. Icarisid II was extracted from icariin by an enzymatic method. In the control and diabetic ED groups, rats were administered normal saline; in the icarisid II group, rats were administered icarisid II intragastrically. Erectile function was evaluated by measuring intracavernosal pressure/mean arterial pressure (ICP/MAP). AGE concentrations, nitric oxide synthase (NOS) activity and cGMP concentration were assessed by enzyme immunoassay. Cell proliferation was analysed using methyl thiazolyl tetrazolium assay and flow cytometry. Autophagosomes were observed by transmission electron microscopy, monodansylcadaverine staining and GFP-LC3 localisation. The expression of NOS isoforms and key proteins in autophagy were examined by western blot. Our results have shown that Icarisid II increased ICP/MAP values, the smooth muscle cell (SMC) growth curve, S phase and SMC/collagen fibril (SMC/CF) proportions and decreased Beclin 1 (P,0.05). Icarisid II significantly increased the proliferative index and p-p70S6K(Thr389) levels and decreased the numbers of autophagosomes and the levels of LC3-II (P,0.01). Icarisid II decreased AGE concentrations and increased cGMP concentration, NOS activity (P,0.05) and cNOS levels (P,0.01) in the diabetic ED group. Therefore, Icarisid II constitutes a promising compound for diabetic ED and might be involved in the upregulation of SMC proliferation and the NO-cGMP pathway and the downregulation of AGEs, autophagy and the mTOR pathway.

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Section: Introductionmentioning

confidence: 99%

Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO–cGMP pathway

Zhang¹,

Li²,

Liu³

et al. 2012

Asian J Androl

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show abstract

“…Increase in mean testosterone concentration supports the submission of Qin et al (2000) that testosterone secretion increased after oral treatment of immature wistar rats and in vitro treatment of cultured leydig cells with flavonoids. Zhang & Yang (2006) had also reported increased level of circulating testosterone in Sprague rats treated with a flavonoid-containing Icariin. One can therefore safely link the flavonoid constituent in Spondias mombin to the increase observed.…”

Section: Discussionmentioning

confidence: 93%

Haemogram and hormonal profile of WAD bucks treated with leaf ethanolic extract of <i>Spondias mombin</i>

Oloye¹,

Ola-Davies²,

Oyeyemi³

2017

Sokoto J. Vet. Sc.

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The goats had well-formed pendulous scrotum with well descended free bilateral testicles. The goats were kept in a standard goat pen and fed with fresh green centrosema leaves in the morning and commercially prepared ration in the evening. Water was served ad libitum. Pre-treatment haematological and hormonal profiling after aseptical collection of blood from the bucks was followed with 14 days of oral treatment with ethanol extract of Spondias mombin at the dosage rate of 800mg/kg BW. Post-treatment haematological and hormonal studies followed after. The hormones assayed were follicle stimulating hormone (FSH), luteinising hormone (LH), testosterone, progesterone, estrogen and prolactin. The haemogram revealed significantly (p < 0.05) higher PCV (24.33±0.6 %) in pre-treatment compared to 19.92± 1.1 % recorded for post-treatment. However, both were lower in values than normal range. WBC and RBC did not change significantly but while RBC values for pre-treatment and post-treatment fell within normal range, only the WBC value of post-treatment did. Assay of FSH, progesterone, estrogen and prolactin revealed no significant (p . 0.05) difference between pre-treatment and post-treatment; however, noticeable higher pre-treatment LH concentration and elevated post-treatment testosterone concentration were observed. The work showed that Spondias mombin at 800mg/kgBW has profertility tendencies in the buck and can be considered as an aphrodisiac in goat breeding in developing countries probably at a higher dosage.

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“…E. longifolia ingestion may also affect testosterone production [12]. Similarly, H. epimedii (‘horny goat weed’), which is typically ingested for its aphrodisiac properties [13], may also mimic the effects of testosterone [14]. Taking into account the long-term ingestion described here, one could conclude that the above three Universal N1-T psychoactive components may have facilitated an increase in testosterone levels.…”

Section: Discussionmentioning

confidence: 98%

Acute Psychotic Episode Associated with the Intake of a Testosterone-Enhancer Herbal Mixture Purchased Online

Minervini¹,

Romanini²,

Solmi³

et al. 2012

Psychother Psychosom

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The testosterone mimetic properties of icariin

Abstract: Icariin has testosterone mimetic properties and has therapeutic potential in the management of hypoandrogenism.

Cited by 79 publications

References 15 publications

Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO–cGMP pathway

Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO–cGMP pathway

Haemogram and hormonal profile of WAD bucks treated with leaf ethanolic extract of <i>Spondias mombin</i>

Acute Psychotic Episode Associated with the Intake of a Testosterone-Enhancer Herbal Mixture Purchased Online

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