The thalamotectal system: An ancient projection for modulating the auditory midbrain

Patel, Mili B.; Sons, Stacy; Yang, Luye; Taha, Gehad A.; Llano, Daniel A.; Lesicko, Alexandria M.H.; Yudintsev, Georgiy

doi:10.1121/2.0000144

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“…Thus, many of these cells resemble paralaminar cells adjacent to the auditory thalamus examined by Smith et al (). In the Smith et al study, paralaminar cells tended to not show bursting, similar to our preliminary observations in mouse thalamotectal cells (Patel et al, ).…”

Section: Discussionsupporting

confidence: 90%

“…Therefore, in the current report we examine: 1) the distribution of thalamic neurons that project to subnuclei of the IC; 2) the presence or absence of staining for the various calcium‐binding proteins in these neurons; 3) whether a component of this pathway is inhibitory; and 4) whether thalamotectal projections are branches of thalamic neurons that project to other forebrain structures, such as the basal ganglia, amygdala, or AC. Earlier versions of this work have been presented in abstract and proceedings form (Patel et al, ). For ease of exposition, we will refer to projections to the IC from the thalamus, peripeduncular areas and brachium of the IC as “thalamotectal,” recognizing that not all of these projections come from the thalamus.…”

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confidence: 99%

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Anatomical characterization of subcortical descending projections to the inferior colliculus in mouse

Patel

Sons

Yudintsev

et al. 2016

J of Comparative Neurology

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Descending projections from the thalamus and related structures to the midbrain are evolutionarily highly conserved. However, the basic organization of this auditory thalamotectal pathway has not yet been characterized. The purpose of this study is to obtain a better understanding of the anatomical and neurochemical features of this pathway. Analysis of the distributions of retrogradely labeled cells after focal injections of retrograde tracer into the inferior colliculus of the mouse revealed that most of the subcortical descending projections originated in the brachium of the inferior colliculus and the paralaminar portions of the auditory thalamus. In addition, the vast majority of thalamotectal cells were found to be negative for the calcium-binding proteins calbindin, parvalbumin or calretinin. Using two different strains of GAD-GFP mice, as well as immunostaining for GABA, we found that a subset of neurons in the brachium of the inferior colliculus is GABAergic, suggesting that part of this descending pathway is inhibitory. Finally, dual retrograde injections into the inferior colliculus and amygdala plus corpus striatum as well into the inferior colliculus and auditory cortex did not reveal any double labeling. These data suggest that the thalamocollicular pathway comprises a unique population of thalamic neurons that do not contain typical calcium binding proteins and do not project to other paralaminar thalamic forebrain targets, and that a previously undescribed descending GABAergic pathway emanates from the brachium of the inferior colliculus.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%