The purpose of this study was to determine the effect of health promotion with social media and booklets on students' knowledge and attitudes about HIV/Aids. This research uses Quasi Experimental method with pretest-posttest control group design. The sampling technique used is random sampling, and analyzed by t-test with the Stata 13 program. The population in this study were students of Kusuma Husada University Surakarta batch 2019 of the Bachelor of Nursing Study Program. The sample in this study used random sampling, with only 17 people randomized per class. Then from the total, a total of 102 sampling subjects were taken. Data collection in this study was carried out using a questionnaire instrument used to guide the interview. Questionnaires are data collection tools used in interviews containing a list of well-structured and matured questions. Questionnaires in uni research include, knowledge, attitudes. The data that has been obtained from filling out the questionnaire is then processed and analyzed using SPSS version 23 software. Based on the results of the bivariate analysis with the following results students' knowledge of HIV after the intervention for the intervention group was 51 people (Mean 27.88; SD 3.59) students' knowledge about HIV after the intervention for the control group was 51 people (Mean 22.50; SD 3.30) with a significant value of knowledge students about HIV after the intervention was (p < 0.001) with an effect size value (ES = 1.55). Bivariate analysis with the results of student attitudes about HIV after the intervention for the intervention group as many as 51 people (Mean 63.43 SD: 6.89) student attitudes about HIV after the intervention for the control group as many as 51 people (mean 44.01 SD 8.58) with a significant value of student attitudes about HIV after the intervention of (p<0.001) with an effect size value (ES=2.39).