Abstract. This article aims to explore the key issues about the construction of the Business English major according to the guideline of the National Standards for Teaching Quality of Business English Major in College. The key issues include the background of setting the national standard, the definition and content of the major, the goals of cultivating talents of the major, the knowledge and ability talents have, construction of the curriculum systems, construction of the teaching staff in the application-oriented college. By using the method of literature and theoretical analysis, the article comes to a conclusion, that is the complete curriculum system, the mode of cultivating talents and good quality of the teaching staff can assure the sustainable development of Business English Major in application-oriented college.