The Theory and Practice of Industrial Pharmacy

Banker, Gilbert S.

doi:10.1002/jps.2600591046

Cited by 101 publications

(134 citation statements)

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“…The angle of repose was found in the range of 23.5±0.4 to 34.4 ± 0.6º and compressibility indices in the range 13.8±0.7 to 23.6±0.6% % suggesting good flowability of particles (Banker, Anderson, 1986). The release studies of all microparticles (NIM-1 to NIM-3) were carried out by dissolution data in phosphate buffer pH 6.8.…”

Section: Resultsmentioning

confidence: 99%

Effect of processing variables and in-vitro study of microparticulate system of nimesulide

Dashora¹,

Saraf²

2007

Rev. Bras. Cienc. Farm.

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Section: Resultsmentioning

confidence: 99%

Effect of processing variables and in-vitro study of microparticulate system of nimesulide

Dashora¹,

Saraf²

2007

Rev. Bras. Cienc. Farm.

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“…The density is normally proportional to the number of spherical particles present in the bulk, and inversely proportional to the size of particles [24]. Notwithstanding this, out of all the nine granule formulations, M9 (the optimized formulation) had the largest granules, as well as the highest bulk and tapped densities ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Nanjwade¹,

Mhase²,

Manvi³

2011

Trop. J. Pharm Res

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“…The gum powder was carefully poured through the funnel until the apex of the conical pile just touched the tip of the funnel. The radius of the base (r) of the pile was determined and the tangent angle of the repose (θ) was calculated by following equation (Banker, Anderson, 1991).…”

Section: Angle Of Repose Methodsmentioning

confidence: 99%

Formulation of gastroretentive floating drug delivery system using hydrophilic polymers and its in vitro characterization

Meka

Dharmanlingam

Kolapalli

2014

Braz. J. Pharm. Sci.

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The aim of the present research is to formulate and evaluate the gastroretentive floating drug delivery system of antihypertensive drug, propranolol HCl. Gastroretentive floating tablets (GRFT) were prepared by using a synthetic hydrophilic polymer polyethylene oxide of different grades such as PEO WSR N-12 K and PEO 18 NF as release retarding polymers and calcium carbonate as gas generating agent. The GRFT were compressed by direct compression strategy and the tablets were evaluated for physicochemical properties, in vitro buoyancy, swelling studies, in vitro dissolution studies and release mechanism studies. From the dissolution and buoyancy studies, F 9 was selected as an optimized formulation. The optimized formulation followed zero order rate kinetics with non-Fickian diffusion mechanism. The optimized formulation was characterised with FTIR studies and observed no interaction between the drug and the polymers.Uniterms: Gastroretentive floating/ drug delivery system. Gastroretentive floating tablets/in vitro dissolution. Hydrophilic polymers/use in drug delivery system. Polyethylene oxide. Propranolol HCl/ delivery system. O objetivo da presente pesquisa é o de formular e avaliar o sistema de liberação de fármaco gastrorretentivo flutuante, contendo o anti-hipertensivo, cloridrato de propranolol. Comprimidos gastrorretentivo flutuantes (GRFT) foram preparados utilizando um polímero hidrofílico sintético, o óxido de polietileno, de diferentes graus, tais como GE WSR N-12 K e GE 18 NF, como polímeros de retardamento de liberação, e carbonato de cálcio, como agente gerador de gases. Os GRFT foram comprimidos por compressão direta e avaliados para determinação das propriedades físico-químicas, flutuabilidade in vitro, estudos de inchamento, de dissolução in vitro e de mecanismo de liberação. Dos testes de dissolução e de flutuabilidade, selecionou-se F 9 como formulação otimizada. A formulação otimizada seguiu cinética de ordem zero, com mecanismo de difusão não-Fickiano. Essa formulação foi caracterizada por estudos de FTIR, não se observando interação entre o fármaco e os polímeros.Unitermos: Retenção gástrica flutuante/sistema de liberação de fármaco. Comprimidos gastrorretentivo flutuante/dissolução in vitro. Polímeros hidrofílicos/uso em sistema de liberação de fármaco. Óxido de polietileno. Cloridrato de propranolol/ sistema de liberação.

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The Theory and Practice of Industrial Pharmacy

Cited by 101 publications

References 0 publications

Effect of processing variables and in-vitro study of microparticulate system of nimesulide

Effect of processing variables and in-vitro study of microparticulate system of nimesulide

Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

Formulation of gastroretentive floating drug delivery system using hydrophilic polymers and its in vitro characterization

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