The Therapeutic Application of the Plasma Substitute Physiogel� in Anesthesiology and Surgery

Tschirren, B; Stampfli, K

doi:10.1159/000384873

Cited by 3 publications

(4 citation statements)

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“…Moreover, the therapeutic application of modified gelatin as a plasma substitute has never been associated with an otherwise un explained increase in bleeding tendency [23].…”

Section: Discussionmentioning

confidence: 99%

Separation of Platelet Rich Plasma and Red Cells with Modified Gelatin

Kummer¹,

Schwander²,

Dezaules³

et al. 1973

Vox Sanguinis

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The reparation of platelet rich plasma (PRP) by acceleration of red cell sedimentation with modified gelatin is evaluated. The mean recordings in the supernatants of 25 blood units after a sedimentation time of 92 min are a platelet yield of 88 % and less than 1 % of red cells in 60 % of the phlebotomy volume. The addition of modified gelatin to freshly drawn blood did not alter the platelet function or viability as measured by in vitro aggregation to ADP, adhesion to glass bead columns, bleeding time following a load of 1,500 ml in surgical patients and survival in normal recipients after storage at 22 °C to 72 h. PRP preparation with modified gelatin necessitates a minimal mechanical equipment and may therefore prove particularly valuable for platelet substitution in nonhospitalized patients.

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“…Moreover, the therapeutic application of modified gelatin as a plasma substitute has never been associated with an otherwise un explained increase in bleeding tendency [23].…”

Section: Discussionmentioning

confidence: 99%

Separation of Platelet Rich Plasma and Red Cells with Modified Gelatin

Kummer¹,

Schwander²,

Dezaules³

et al. 1973

Vox Sanguinis

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“…Following the infusion of large doses of gelatin, the activity of plasmatic coagulation factors is reduced in proportion to the hernodilution attained. However, no manifest bleeding tendency results [16,63,88,212,213,2141. When gelatin is used t o prime extracorporeal circuits, the alterations of the coagulation status are the same as those induced by 5% glucose yielding the same degree of hemodilution [210].…”

Section: Hemostatic Impairmentmentioning

confidence: 99%

Treatment of Shock with Dextrans and Gelatins

Lundsgaard-Hansen

1969

Vox Sanguinis

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The effects and side effects of dextran and gelatin plasma substitutes relevant to the treatment of shock are reviewed. The physico-chemical characteristics give the dextrans a certain lead over the gelatins with respect to molecular weight, intravascular volume effect and retention period. Experimental studies and clinical experience, however, have failed to demonstrate any difference of their therapeutic value, as revealed by survival data and suppression of shock-induced metabolic alterations. Severe allergic reactions may occur with dextrans, but have not so far been recorded with gelatins. Hemostatic impairment limits the tolerated dose of clinical dextran, the risk of renal damage that of low molecular weight dextran. Similar side effects of the gelatins have not been documented. The risk of overtransfusion is greater with dextrans than with gelatins. The lower potency of the gelatins would appear, therefore, to be a t least outweighed by their freedom from side effects, which enlarges the therapeutic margin of safety for shock treatment with artificial colloids.

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“…Follo wing the infusion of large doses of gelatin, the activity of plasmatic coagulation factors is reduced in proportion to the hemodilution attained. However, no manifest bleeding tendency results [16,63,88,212,213,214]. When gelatin is used to prime extracorporeal circuits, the alterations of the coagulation status are the same as those induced by 5% glucose yielding the same degree of hemo dilution [210].…”

Section: Hemostatic Impairmentmentioning

confidence: 99%

“…The exchange of half the normal blood volume with gelatin preparations [93,211], even if aggravated by the addi tional stress of extracorporeal perfusion [211], does not cause renal damage. Nor does the infusion of gelatins in amounts equalling the total normal blood volume as an emergency treatment of large blood losses in man [212,213]. Clearly, however, the specific gravity of the urine does not reflect renal function following gelatin infusions either.…”

Section: Products Division Travenol Laboratories Internationmentioning

confidence: 99%

Treatment of Shock with Dextrans and Gelatins

1969

Vox Sanguinis

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The Therapeutic Application of the Plasma Substitute Physiogel� in Anesthesiology and Surgery

Cited by 3 publications

References 0 publications

Separation of Platelet Rich Plasma and Red Cells with Modified Gelatin

Separation of Platelet Rich Plasma and Red Cells with Modified Gelatin

Treatment of Shock with Dextrans and Gelatins

Treatment of Shock with Dextrans and Gelatins

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