The therapeutic, diagnostic, and prognostic values of extracellular vesicles (exosomes) in dermatology: A systematic review

Novis, Taissa; Gomes Menezes, Adriano Henrique; Vilaça Lima, Luan Cavalcante; Lötvall, Jan; Borges do Nascimento, Israel Júnior; Maeda Takiya, Christina

doi:10.1016/j.jdrv.2024.06.006

JAAD Reviews

2024

DOI: 10.1016/j.jdrv.2024.06.006

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The therapeutic, diagnostic, and prognostic values of extracellular vesicles (exosomes) in dermatology: A systematic review

Taissa Novis,

Adriano Henrique Gomes Menezes,

Luan Cavalcante Vilaça Lima

et al.

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2024

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Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review

Gupta,

Wang,

Rapaport

et al. 2024

J of Cosmetic Dermatology

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BackgroundThere are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet‐rich plasma represents an abundant source of exosomes.AimTo present evidence on the use of platelet‐rich plasma‐derived exosomes in dermatology and discuss current technical limitations.MethodsA literature search was conducted using Embase (Ovid), Web of Science, and ClinicalTrials.gov in June 2024.ResultsPlatelet‐rich plasma‐derived exosomes contain a myriad of growth factors, genetic materials, and lipids that mediate paracrine signaling. Several preclinical studies have demonstrated their potential in wound healing. This includes faster wound contraction in diabetic animal models, as well as enhanced angiogenesis, increased cell proliferation and migration, and protection against hyperglycemic conditions in vitro. A case study reported a topical platelet‐derived exosome product tried successfully in a patient with persistent scalp wounds. In contrast, there is scarce information on the use of platelet‐rich plasma‐derived exosomes in hair growth and skin rejuvenation. Isolation techniques, activation methods, and methods of delivery have not been optimized, which warrants further research. Novel delivery methods, such as hydrogel‐based preparations, may enable the topical application of exosomes.ConclusionExosomes derived from platelet‐rich plasma have demonstrated therapeutic potential. More research is needed to standardize its use.

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Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review

Gupta,

Wang,

Rapaport

et al. 2024

J of Cosmetic Dermatology

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show abstract

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The therapeutic, diagnostic, and prognostic values of extracellular vesicles (exosomes) in dermatology: A systematic review

Cited by 1 publication

References 88 publications

Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review

Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review

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