The Therapeutic Effect of Acanthopanax senticosus Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters

Song, Chen; Li, Sijia; Duan, Fangyuan; Liu, Mengyao; Shan, Shan; Ju, Ting; Zhang, Yingchun; Lu, Weihong

doi:10.3390/molecules27031106

Cited by 15 publications

(8 citation statements)

References 46 publications

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“…AS is a medicinal plant in the family of Araliaceae. Previous studies have shown that the active ingredients of AS can significantly improve blood lipid levels and endothelial cell function in patients with acute cerebral infarction, promote the proliferation of neural stem cells in ischemic brain tissue and have therapeutic effects on cerebrovascular diseases such as hypertension and cerebral infarction [18][19][20]. In addition, AS has a sedative effect on the central nervous system, which can improve anxiety, irritability, insomnia, and other symptoms, and is commonly used clinically for the treatment of abnormal affective disorders and neurological disorders [21][22].…”

Section: Discussionmentioning

confidence: 99%

Efficient Extraction and Purification of Isofraxidin from Acanthopanax Senticosus by DES

Sun¹,

Hou²,

Sun³

et al. 2023

Preprint

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Acanthopanax senticosus(rupr. rt. Maxim.; AS) is a medicinal plant used in the clinical treatment of cerebrovascular diseases and central nervous system disorders, significantly improving blood lipid levels and endothelial cell function in patients with acute cerebral infarction. Isofraxidin, one of the active ingredients of AS, is the core of the medical effects, and its extraction and purification depend on organic solvents. Deep eutectic solvents (DESs) is a new green solvent, synthesized by intermolecular hydrogen bonding between hydrogen bond donors (HBD) and hydrogen bond acceptors (HBA), which has non-toxic, high separation and purification efficiency, and environmentally friendly compared with traditional organic solvents. In this paper, DES was used for the extraction of isofraxidin from AS. The primary findings demonstrate that the DESs had a viscosity higher than that of ethanol, and even adding a tiny amount of water (about 10%) would trigger solvent redistribution, leading to a considerable reduction in solvent viscosity. In comparison to ethanol, the extraction rate of isofraxidin by DESs was 2-3 times higher. Thus, this work developed a new technique for using green extraction of isofraxidin that has some practical implications.

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Section: Discussionmentioning

confidence: 99%

Efficient Extraction and Purification of Isofraxidin from Acanthopanax Senticosus by DES

Sun¹,

Hou²,

Sun³

et al. 2023

Preprint

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“…Dried root ethanolic extract from AS has been found to scavenge superoxide anion and hydroxyl radicals [ 4 ]. CA and CGA isolated from AS have antioxidant activities [ 5 ], whereas EB and EE have no significant antioxidant (anti-DPPH) properties [ 6 , 8 ]. To extend these observations, CA, CGA, PCA, EB and EE as ASRE components [ 2 ] were selected for our study.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, AS positively influences the central nervous system, prevents and treats respiratory infections and improves physical fatigue effects [ 1 , 2 , 3 ]. AS extracts, as adaptogens, increase adaptability and survival of organisms under stress, where observed antioxidant properties can positively contribute to the effects [ 2 , 4 , 5 , 6 , 7 , 8 ]. Polysaccharides, flavones and several dozen individual compounds were isolated from AS having numerous biological effects [ 2 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…AS extracts, as adaptogens, increase adaptability and survival of organisms under stress, where observed antioxidant properties can positively contribute to the effects [ 2 , 4 , 5 , 6 , 7 , 8 ]. Polysaccharides, flavones and several dozen individual compounds were isolated from AS having numerous biological effects [ 2 , 8 ]. The AS component chlorogenic acid (CGA) is a naturally occurring nonflavonoid polyphenol that exerts numerous biological effects, e.g., antiviral, antitumor, antibacterial, antioxidant, antiinflammatory, antilipidemic, antidiabetic, antihypertensive and antimicrobial activity [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Extract of Acanthopanax senticosus and Its Components Interacting with Sulfide, Cysteine and Glutathione Increase Their Antioxidant Potencies and Inhibit Polysulfide-Induced Cleavage of Plasmid DNA

et al. 2022

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Aqueous root extract from Acanthopanax senticosus (ASRE) has a wide range of medicinal effects. The present work was aimed at studying the influence of sulfide, cysteine and glutathione on the antioxidant properties of ASRE and some of its selected phytochemical components. Reduction of the 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide (●cPTIO) stable radical and plasmid DNA (pDNA) cleavage in vitro assays were used to evaluate antioxidant and DNA-damaging properties of ASRE and its individual components. We found that the interaction of ASRE and its two components, caffeic acid and chlorogenic acid (but not protocatechuic acid and eleutheroside B or E), with H2S/HS−, cysteine or glutathione significantly increased the reduction of the ●cPTIO radical. In contrast, the potency of ASRE and its selected components was not affected by Na2S4, oxidized glutathione, cystine or methionine, indicating that the thiol group is a prerequisite for the promotion of the antioxidant effects. ASRE interacting with H2S/HS− or cysteine displayed a bell-shaped effect in the pDNA cleavage assay. However, ASRE and its components inhibited pDNA cleavage induced by polysulfides. In conclusion, we suggest that cysteine, glutathione and H2S/HS− increase antioxidant properties of ASRE and that changes of their concentrations and the thiol/disulfide ratio can influence the resulting biological effects of ASRE.

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“…AS and its extract are widely used in Russia and East Asian countries for specific pharmacological effects involving anticancer, anti‐inflammatory, and cardiovascular protection potencies. It improves physical fatigue effects and increases the survival of organisms under stress 13–19 . AS is also used to treat hypertension and ischemic heart disease in the traditional Chinese system of medicine 20 .…”

Section: Introductionmentioning

confidence: 99%

Use of a rat model to characterize 35 arterial pulse wave parameters in a comparative study of isoflurane and Zoletil/xylazine anesthesia and the effect ofAcanthopanax senticosusextract

Misak,

Grman,

Tomasova

et al. 2023

Anim Models and Exp Med

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BackgroundInformation obtained from arterial pulse waveforms (APW) can be useful for characterizing the cardiovascular system. To achieve this, it is necessary to know the detailed characteristics of APWs in different states of an organism, which would allow APW parameters (APW‐Ps) to be assigned to particular (patho)physiological conditions. Therefore, our work aimed to characterize 35 APW‐Ps in rats under the influence of isoflurane (ISO) and Zoletil/xylazine (ZO/XY) anesthesia and to study the effect of root extract from Acanthopanax senticosus (ASRE) in these anesthetic conditions.MethodsThe right jugular vein of anesthetized rats was cannulated for the administration of ASRE and the left carotid artery for the detection of APWs from which 35 APW‐Ps were evaluated.ResultsWe obtained data on 35 APW‐Ps, which significantly depended on the anesthesia, and thus, they characterized the cardiovascular system under these two conditions. ASRE transiently modulated all 35 APW‐Ps, including a transient decrease in systolic and diastolic blood pressure (BP) and heart rate or increases in pulse BP, dP/dtmax, and systolic and diastolic areas. Whereas the transient effects of ASRE were similar, the extract had prolonged disturbing effects on the cardiovascular system in rats under ZO/XY but not under ISO anesthesia. This negative effect can result from the disturbance caused by ZO/XY anesthesia on the cardiovascular system.ConclusionsWe characterized 35 APW‐Ps of rats under ISO and ZO/XY anesthesia and found that ASRE contains compounds that can modulate the properties of the cardiovascular system, which significantly depended on the status of the cardiovascular system. This should be considered when using ASRE as a nutritional supplement by individuals with cardiovascular problems.

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The Therapeutic Effect of Acanthopanax senticosus Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters

Cited by 15 publications

References 46 publications

Efficient Extraction and Purification of Isofraxidin from Acanthopanax Senticosus by DES

Efficient Extraction and Purification of Isofraxidin from Acanthopanax Senticosus by DES

Extract of Acanthopanax senticosus and Its Components Interacting with Sulfide, Cysteine and Glutathione Increase Their Antioxidant Potencies and Inhibit Polysulfide-Induced Cleavage of Plasmid DNA

Use of a rat model to characterize 35 arterial pulse wave parameters in a comparative study of isoflurane and Zoletil/xylazine anesthesia and the effect ofAcanthopanax senticosusextract

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