The Therapeutic Effect of Changyuning Granules Combined With Retention Enema on Alleviating the Symptoms of Ulcerative Colitis

Abstract

Ulcerative colitis (UC) is an inflammatory bowel disease that lacks an effective treatment without severe side effects. In this study, we aimed to evaluate the clinical efficacy of Changyuning granules (CYNG) combined with retention enema on patients with ulcerative colitis (UC) evaluating the effects on the intestinal mucosa of patients. Ninety-six patients with UC were randomly divided into observation group and control group (48 cases in each group). Patients in the control group were treated for 12 weeks with Kuiyangling enema, and the observation group was treated with CYNG plus Kuiyangling enema. Both types of treatment can improve the main clinical symptoms such as diarrhoea, bloody purulent stool, abdominal pain, the effects being superior after CYNG treatment. The total effective rate of the observation group is higher than that of the control group. The treatment with CYNG plus Kuiyangling enema is superior to the treatment with Kuiyangling enema in reducing intestinal mucosal lesions, inhibiting the expression of TLR4, reducing inflammation, promoting the recovery of intestinal mucosal function, and improving the immune function of patients. In conclusion, CYNG combined with Kuiyangling enema has a good clinical effect in the treatment of UC, which can significantly improve intestinal mucosal inflammation, promote the recovery of intestinal mucosal function, and improve the immune function of patients with minimum side effects. RezumatColita ulcerativă (UC) este o boală inflamatorie intestinală care nu beneficiază de un tratament eficient, fără efecte secundare severe. În acest studiu, ne-am propus să evaluăm eficacitatea clinică a granulelor Changyuning (CYNG) combinate cu clisma de retenție la pacienții cu UC, evaluând efectele asupra mucoasei intestinale a pacienților. Nouăzeci și șase de pacienți cu UC au fost împărțiți aleatoriu în grupul de studiu și grupul control (48 de cazuri în fiecare grup). Pacienții din grupul control au fost tratați timp de 12 săptămâni cu clismă Kuiyangling, iar grupul de studiu a fost tratat cu CYNG, pe lângă clisma Kuiyangling. Ambele tipuri de tratament pot ameliora principalele simptome clinice precum diaree, scaun purulent sângeros, dureri abdominale, efectele înregistrate fiind superioare după tratamentul cu CYNG. Tratamentul cu clisma Kuiyangling plus CYNG a fost superior tratamentului cu clisma Kuiyangling în reducerea leziunilor mucoasei intestinale, inhibarea expresiei TLR4, reducerea inflamației, promovarea recuperării funcției mucoasei intestinale și îmbunătățirea funcției imune a pacienților.

Anti-Inflammatory Effect of Monoammonium Glycyrrhizinate on Experimental Colitis

“…Macrophage activation and increased production of cytokines such as TNF-alpha, IL-1 and IL-6 also contribute to the inflammatory response. Studies have shown the role of genetic factors in the development of IBD through disruption of the integrity of the epithelial barrier [24], deficiency of autophagocytosis [23], congenital defects in receptor populations and problems related to the lymphocyte differentiation, especially in Crohn's disease [28,29]. This study aimed to evaluate the anti-inflammatory activity of monoammonium glycyrrhizinate on experimental colitis induced by 2,4-dinitrobenzenesulfonic acid hydrate (DNBS) in Wistar rats.…”