The therapeutic effects of Agrimonia eupatoria L.

Paluch, Zoltán; Biriczová, L; Pallag, Gergely; Marques, E Carvalheiro; Vargová, N; Kmoníčková, Eva

doi:10.33549/physiolres.934641

Cited by 20 publications

(10 citation statements)

References 100 publications

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“…It has been used for gastrointestinal disorders, diarrhea, cholecystitis, pneumonia, hepatopathy, pyelonephritis, cystitis, bleeding disorders, skin defects, and oral mucosal inflammatory diseases [ 13 , 14 ]. The results of published studies have confirmed its anti-inflammatory, astringent, diuretic, antimicrobial, antiviral, antioxidant, neuroprotective, and hepatoprotective effects, as well as many others [ 15 ]. It contains a number of secondary metabolites (polyphenols, tannins, flavonoids) with the ability to reduce silver to nanoscale silver.…”

Section: Introductionmentioning

confidence: 90%

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Balážová

Wolaschka

Rohaľová

et al. 2023

Life

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Silver nanoparticles (Ag NPs) with antibacterial activity can be prepared in different ways. In our case, we used ecological green synthesis with Agrimonia eupatoria L. The plant extract was used with Ag NPs for the first time to prepare termosensitive in situ gels (ISGs). Such gels are used to heal human or animal skin and mucous membranes, as they can change from a liquid to solid state after application. Ag NPs were characterized with various techniques (FTIR, TEM, size distribution, zeta potential) and their antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. In accordance with the TEM data, we prepared monodispersed spherical Ag NPs with an average size of about 20 nm. Organic active compounds from Agrimonia eupatoria L. were found on their surfaces using FTIR spectroscopy. Surprisingly, only the in situ gel with Ag NPs showed antibacterial activity against Escherichia coli, while Ag NPs alone did not. Ag NPs prepared via green synthesis using plants with medicinal properties and incorporated into ISGs have great potential for wound healing due to the antibacterial activity of Ag NPs and the dermatological activity of organic substances from plants.

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Section: Introductionmentioning

confidence: 90%

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Balážová

Wolaschka

Rohaľová

et al. 2023

Life

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“…Scientific reports have indicated that plant products obtained from the aerial parts of Agrimonia eupatoria L. have great pharmaceutical and biological potential, including the recently revealed in vitro anticoagulant activity [16], due to the conjugates of pectin-like polysaccharides with macromolecular polyphenolic matrices. Other well-described small molecule polyphenols from A. eupatoria, including flavonoids, phenolic acids, coumarins, tannins, and terpenoids, have demonstrated beneficial health effects mostly due to their well-known free radical scavenging properties [13,[17][18][19][20][21]. Literature studies have shown that A. eupatoria tissues are especially rich in various flavonoid glycosides, such as luteolin, acacetin, apigenin, quercetin, kaempferol, kaempferide, and rutin [17,[22][23][24], in addition to some flavonols, i.e., catechin, epicatechin and its polymers, myricetin and isorhamnetin, and phenolic acids, i.e., p-coumaric, vanillic, gentisic, p-hydroxybenzoic, and hydroxycinnamic acids [16,17,25,26].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Protective Effects of the Polyphenolic Glycoconjugate from Agrimonia eupatoria L. Herb in the Prevention of Inflammation in Human Cells

Tsirigotis-Maniecka

Zaczyńska

Czarny

et al. 2023

JFB

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Herein, structural and biological studies of a complex biopolymer (polyphenolic glycoconjugate) isolated from the flowering parts of Agrimonia eupatoria L. (AE) are presented. Spectroscopic analyses (UV–Vis and 1H NMR) of the aglycone component of AE confirmed that it consists mainly of aromatic and aliphatic structures characteristic of polyphenols. AE showed significant free radical elimination activity, i.e., ABTS+ and DPPH·, and was an effective copper reducing agent in the CUPRAC test, eventually proving that AE is a powerful antioxidant. AE was nontoxic to human lung adenocarcinoma cells (A549) and mouse fibroblasts (L929) and was nongenotoxic to S. typhimurium bacterial strains TA98 and TA100. Moreover, AE did not induce the release of proinflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor (TNF-α) by human pulmonary vein (HPVE-26) endothelial cells or human peripheral blood mononuclear cells (PBMCs). These findings correlated with the low activation of the transcription factor NF-κB in these cells, which plays an important role in the regulation of the expression of genes responsible for inflammatory mediator synthesis. The AE properties described here suggest that it may be useful for protecting cells from the adverse consequences of oxidative stress and could be valuable as a biomaterial for surface functionalization.

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“…The aerial parts harvested from the species Agrimonia eupatoria L. are used in phytotherapy for the treatment of gastrointestinal diseases (gastritis, enteritis, peptic ulcer disease, and nonspecific diarrhea). Additionally, they are used in the treatment of biliary or hepatic disorders [38][39][40][41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

The Polyphenolic Profile and Antioxidant Activity of Five Vegetal Extracts with Hepatoprotective Potential

Costea

Chiţescu

Boscencu

et al. 2022

Plants

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Oxidative stress is among the major triggers for many important human functional disorders, which often lead to various metabolic or tissue diseases. The aim of the study is to obtain five standardized vegetal extracts (Cynarae extractum—CE, Rosmarini extractum—RE, Taraxaci extractum—TE, Cichorii extractum—CHE, and Agrimoniae extractum—AE) that contain active principles with an essential role in protecting liver cells against free radicals and quantify their antioxidant actions. The compounds of therapeutic interest from the analyzed extracts were identified and quantified using the UHPLC–HRMS/MS technique. Thus, the resulting identified compounds were 28 compounds in CE, 48 compounds in RE, 39 compounds in TE, 43 compounds in CHE, and 31 compounds in AE. These compounds belong to the class of flavonoids, isoflavones, phenolic acids and dicarboxylic acids, depsides, diterpenes, triterpenes, sesquiterpenes, proanthocyanidins, or coumarin derivatives. From the major polyphenolic compounds quantified in all the extracts analyzed by UHPLC–HRMS/MS, considerable amounts have been found for chlorogenic acid (619.8 µg/g extract for TE–2032.4 µg/g extract for AE), rutoside (105.1 µg/g extract for RE–1724.7 µg/g extract for AE), kaempferol (243 µg/g extract for CHE–2028.4 µg/g extract for CE), and for naringenin (383 µg/g extract for CHE–1375.8 µg/g extract for AE). The quantitative chemical analysis showed the highest content of total phenolic acids for AE (24.1528 ± 1.1936 g chlorogenic acid/100 g dry extract), the highest concentration of flavones for RE (6.0847 ± 0.3025 g rutoside/100 g dry extract), and the richest extract in total polyphenols with 31.7017 ± 1.2211 g tannic acid equivalent/100 g dry extract for AE. Several methods (DPPH, ABTS, and FRAP) have been used to determine the in vitro total antioxidant activity of the extracts to evaluate their free radical scavenging ability, influenced by the identified compounds. As a result, the correlation between the content of the polyphenolic compounds and the antioxidant effect of the extracts has been demonstrated. Statistically significant differences were found when comparing the antiradical capacity within the study groups. Although all the analyzed extracts showed good IC50 values, which may explain their antihepatotoxic effects, the highest antioxidant activity was obtained for Agrimoniae extractum (IC50ABTS = 0.0147 mg/mL) and the lowest antioxidant activity was obtained for Cynarae extractum (IC50ABTS = 0.1588 mg/mL). Furthermore, the hepatoprotective potential was evaluated in silico by predicting the interactions between the determined phytochemicals and key molecular targets relevant to liver disease pathophysiology. Finally, the evaluation of the pharmacognostic and phytochemical properties of the studied extracts validates their use as adjuvants in phytotherapy, as they reduce oxidative stress and toxin accumulation and thus exert a hepatoprotective effect at the cellular level.

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The therapeutic effects of Agrimonia eupatoria L.

Cited by 20 publications

References 100 publications

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

In Situ Gel with Silver Nanoparticles Prepared Using Agrimonia eupatoria L. Shows Antibacterial Activity

Antioxidant and Protective Effects of the Polyphenolic Glycoconjugate from Agrimonia eupatoria L. Herb in the Prevention of Inflammation in Human Cells

The Polyphenolic Profile and Antioxidant Activity of Five Vegetal Extracts with Hepatoprotective Potential

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