The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

İlhan, Nevin; Susam, Solmaz; Gül, Hüseyin Fatih

doi:10.5505/tjtes.2018.68473

Cited by 4 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, great effort was made to develop potent inhibitors targeting cytokines like TNF‐α, IL‐1, and IL‐6 or their corresponding receptors leading to the generation of highly specific and effective clinically validated compounds like etanercept, anakinra, and tocilizumab [134]. Based on their efficacy in preclinical sepsis models, great hope has been placed in these small molecular inhibitors and antagonistic monoclonal antibodies [135–138]. However, none of them did add significant benefit for the treatment of sepsis or septic shock in clinical trials.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

Rahn

Becker‐Pauly

2021

FEBS Letters

View full text Add to dashboard Cite

Systemic inflammatory disorders (SIDs) comprise a broad range of diseases characterized by dysregulated excessive innate immune responses. Severe forms of SIDs can lead to organ failure and death, and their increasing incidence represents a major issue for the healthcare system. Protease‐mediated ectodomain shedding of cytokines and their receptors represents a central mechanism in the regulation of inflammatory responses. The metalloprotease A disintegrin and metalloproteinase (ADAM) 17 is the best‐characterized ectodomain sheddase capable of releasing TNF‐α and soluble IL‐6 receptor, which are decisive factors of systemic inflammation. Recently, meprin metalloproteases were also identified as IL‐6 receptor sheddases and activators of the pro‐inflammatory cytokines IL‐1β and IL‐18. In different mouse models of SID, particularly those mimicking a sepsis‐like phenotype, ADAM17 and meprins have been found to promote disease progression. In this review, we summarize the role of ADAM10, ADAM17, and meprins in the onset and progression of sepsis and discuss their potential as therapeutic targets.

show abstract

Section: Summary and Perspectivesmentioning

confidence: 99%

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

Rahn

Becker‐Pauly

2021

FEBS Letters

View full text Add to dashboard Cite

show abstract

“…Ilhan et al found that the administration of thalidomide and etanercept as therapeutic agents resulted in a significant decrease in the level of TNF-α 32 . Ilhan et al conducted an experimental study with etanercept in septic rats and found that serum MDA level significantly decreased following an etanercept treatment 33 . In line with these findings, our results showed that etanercept significantly reduced inflammatory and oxidative stress parameters in sepsis.…”

Section: /7mentioning

confidence: 99%

Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats

Aydın

Yildirim

Aydin

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats. Methods: Twenty-eight adult Sprague Dawley rats were classified into Control (Group 1), Sepsis (Group 2), Sepsis+Cefazolin (Group 3), and Sepsis+Cefazolin+Etanercept (Group 4) groups. Kidney tissue and serum samples were obtained for biochemical and histopathological investigations and examined for the C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), triggering receptor expressed on myeloid cells (TREM), and malondialdehyde (MDA) levels. Results: The levels of TNF-α, TREM, and MDA in serum and kidney samples were significantly higher in rats from sepsis group than in rats from control group (p < 0.05). Group 3 showed a significant reduction in serum levels of TNF-α, CRP, and TREM as compared with Group 2 (p < 0.05). Serum TNF-α, CRP, TREM, and MDA levels and kidney TNF-α and TREM levels were significantly lower in Group 4 than in Group 2 (p < 0.05). Serum TNF-α and TREM levels in Group 4 were significantly lower than those in Group 3, and histopathological scores were significantly lower in Group 3 and Group 4 than in Group 2 (p < 0.05). Histopathological scores of Group 4 were significantly lower than those of Group 3 (p < 0.05). Conclusions: Etanercept, a TNF-α inhibitor, may ameliorate sepsis-induced oxidative stress, inflammation, and histopathological damage.

show abstract

“…Damage to the stomach increases the levels of various proinflammatory cytokines, triggering the recruitment of leukocytes that stimulate inflammatory responses 5 . Tumor necrosis factor-α (TNF-α) stimulates the transcription of inflammatory mediator cytokines such as interleukin-6 (IL-6) and IL-1β 6,7 .…”

Section: Introductionmentioning

confidence: 99%

The protective effect of tangeretin and pomegranate separately and in combination on ethanol-induced acute gastric ulcer model

SUSAM,

İLHAN,

TEDİK

et al. 2023

Cukurova Medical Journal

Self Cite

View full text Add to dashboard Cite

Purpose: This study was designed to find an answer to the question, "Is it beneficial to use pomegranate (POM) and tangeretin (TAN) separately or in combination, for the prevention of acute gastric ulcer?". Materials and Methods: The gastroprotective effect of tangeretin and pomegranate was determined by measuring the levels of the selected inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β and IL-10], lipid peroxides, and enzymatic activities of antioxidants in gastric tissue samples. Results: When all groups are written as control, gastric ulcer, POM+EtOH, TAN+EtOH and POM+TAN+EtOH, respectively; IL-1β cytokine levels were measured as 0.147, 0.24, 0.228, 0.195 and 0.182 pg/g protein. IL-6 levels; 16,857, 25,923, 19,797, 18,838 and 17,896 pg/mg protein. TNF-α levels were 39,916, 49.97, 44,678, 41,673 and 40,844 pg/mg protein. Finally, IL-10 levels were measured as 33,496, 28,071, 29,693, 30,073 and 30,008 pg/mg protein. SOD activities were determined as 18,038, 13,731, 15,506, 14,439, and 15,943. CAT activities were 674,638, 639,964, 673,382, 664,691, and 671,203. Protein carbonyl levels were measured as 26,799, 40,30, 33,052, 34,579 and 32,79. Finally, MDA levels were found as 5,239, 9,814, 6,695, 5,771 and 5,836. Briefly, POM and TAN showed their antioxidant functions by decreasing the levels of malondialdehyde (MDA), and protein carbonyl and increasing the activity of superoxide dismutase (SOD) and catalase (CAT). And also, these protective agents exhibited their anti-inflammatory functions by decreasing the content of TNF-α, IL-6, and IL-1β, and increasing the IL-10 levels. Conclusion: Tangeretin and pomegrenate have a potential gastroprotective effect against ethanol-induced acute gastric ulcer and that the combined treatment is more beneficial than the effect of POM or TAN alone. In addition, this effect is thought to be due to the fact that both selected flavonoids can show a synergistic effect, reducing the levels of inflammation parameters and increasing antioxidant levels.

show abstract

The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

Cited by 4 publications

References 31 publications

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats

The protective effect of tangeretin and pomegranate separately and in combination on ethanol-induced acute gastric ulcer model

Contact Info

Product

Resources

About