The therapeutic perspective of cold atmospheric plasma in periodontal disease

Abstract

ObjectivesPeriodontal disease (PD) is one of the most common infectious diseases with complex inflammatory conditions, having irreversibly destructive impacts on the periodontal supporting tissues. The application of cold atmospheric plasma (CAP) is a promising adjuvant therapy modality for PD. However, the mechanism of CAP in PD treatment is still poorly understood. The review motivates to outline the latest researches concerning the applications of CAP in PD treatment.MethodsWe searched CAP‐related literature through utilizing the well‐established databases of Pubmed, Scopus and Web of Science according to the following keywords related to periodontal disease (periodontal, gingival, gingivitis, gingiva, periodontium, periodontitis).ResultsA total of 18 concerning original studies were found. These studies could be classified according to three pathophysiological perspectives of PD. The therapeutic mechanisms of CAP may be attributed to the oxidative stress‐related cell death of periodontal bacteria, the suppression of periodontal inflammation and pro‐inflammatory cytokine secretion, as well as the acceleration of periodontal soft tissue wound healing and hard tissue reconstruction.ConclusionsCold atmospheric plasma has potential therapeutic effects on PD through three mechanisms: antimicrobial effect, inflammation attenuation, and tissue remodeling. This review hopefully provides a comprehensive perspective into the potential of CAP in PD therapy.

The applications of cold atmospheric plasma in dentistry

“…Figures 2 and 4 summarize the most frequent applications and types of cells used in recent research on tissue regeneration in dentistry. [57,98,[102][103][104][105][106][107][108][109]…”

Enhanced Antimicrobial Activity through Synergistic Effects of Cold Atmospheric Plasma and Plant Secondary Metabolites: Opportunities and Challenges

“…CAP is found to be effective against a wide range of muti-drug-resistant bacteria and biofilms [16,[42][43][44]. There are several mechanisms by which CAP induces antimicrobial effect [45].…”

“…Cold atmospheric plasma (CAP) is a non-thermal technology that is attracting interest as an alternative therapy for various medical conditions [12][13][14]. CAP is typically generated by passing a gas through an electrical discharge, creating a plasma that contains reactive species such as reactive oxygen and nitrogen species (ROS and RNS), ions, electrons, and UV photons [15,16]. These species can interact with biological materials and have been shown to have a wide range of therapeutic effects, including antimicrobial, anti-inflammatory, and wound-healing properties [15].…”