The therapeutic potential for tryptophan and melatonin: Possible roles in depression, sleep, Alzheimer's disease and abnormal aging

Maurizi, C.P.

doi:10.1016/0306-9877(90)90097-x

Cited by 31 publications

(19 citation statements)

References 98 publications

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“…28 Tryptophan, serotonin, and melatonin have also been reported to have potent anxiolytic effects. 2 Corroborating the findings that Night milk has sedative and anxiolytic or relaxing effects is the result of the pentobarbital-induced sleeping test, wherein the Night milk administration shortened the onset and prolonged the duration of sleep (Fig. 3).…”

Section: Discussionmentioning

confidence: 92%

“…1 Tryptophan can be converted to serotonin and melatonin, consequently inducing relaxation and sleepiness. 2 Melatonin is a naturally occurring hormone, secreted by the pineal gland, which helps regulate the sleep and wake cycle (circadian rhythm). 3,4 Accordingly, in humans and animals alike, melatonin is known to be at its highest concentration at night and during sleep.…”

Section: Introduction Mmentioning

confidence: 99%

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Milk Collected at Night Induces Sedative and Anxiolytic-Like Effects and Augments Pentobarbital-Induced Sleeping Behavior in Mice

Joy

HongEunyoung

Bryan

et al. 2015

Journal of Medicinal Food

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Milk has long been known and used to promote sleep. The sleep-promoting effect of milk has been attributed to its psychological associations (i.e., the memory of a mother giving milk at bedtime) and its rich store of sleep-promoting constituents (e.g., tryptophan). Studies have shown that milk harvested at night (Night milk) contains exceptionally high amounts of tryptophan and melatonin. In the present study, we evaluated the psychopharmacological properties of Night milk, particularly its probable sleep-promoting/enhancing, and anxiolytic effects. Night milk was orally administered to ICR mice at various concentrations (100, 200, or 300 mg/kg). An hour after administration, assessment of its sedative (open-field and rotarod tests) and sedative sleep-potentiating effects (pentobarbital-induced sleeping test) was conducted. For comparison, the effects of Day milk (daytime milking) were also assessed. In addition, the effects of Night milk on anxiety behavior (elevated plus maze [EPM] test) and electroencephalographic (EEG) waves were evaluated. Night milk-treated animals exhibited decreased spontaneous locomotion (open-field test) and impaired motor balance and coordination (rotarod test). Furthermore, Night milk shortened the sleep onset and prolonged the sleep duration induced by pentobarbital sodium. These effects were comparable to that of diazepam. In addition, Night milk significantly increased the percentage of time spent and entries into the open arms of the EPM, indicating that it also has anxiolytic effects. No significant changes in EEG waves were observed. Altogether, these findings suggest that Night milk is a promising natural aid for sleep-and anxiety-related disturbances.

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Section: Discussionmentioning

confidence: 92%

Section: Introduction Mmentioning

confidence: 99%

Milk Collected at Night Induces Sedative and Anxiolytic-Like Effects and Augments Pentobarbital-Induced Sleeping Behavior in Mice

Joy

HongEunyoung

Bryan

et al. 2015

Journal of Medicinal Food

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“…There were 2 references cited by the North American Clinics in Psychiatry (Lebert et al, 1994;Zisselman et al, 1996), 7 by the AAN (Burke et al, 1995;Holton & George, 1985;Houlihan et al, 1994;Lebert et al, 1994;Nyth et al, 1992;Nyth & Gottfries, 1990;Reifler et al, 1989) and 11 by the APA (Colenda, 1988;Conti et al, 1989;Fuchs et al, 1993;Maurizi, 1990;Nyth et al, 1992;Nyth & Gottfries, 1990;Passeriet al, 1993;Picket et al, 1990;Price & McAllister, 1989;Reifler et al, 1989;Wallace et al, 1995). It is noteworthy that of the seven references used by the AAN, only two were "shared" by the APA (Nyth & Gottfries, 1990;Reifler et al, 1989).…”

Section: Swartz Et Almentioning

confidence: 96%

“…O t h e r s : Tryptophan, melatonin (Maurizi, 1990), methyltetrahydrofolic acid (Passeri et al, 1993), and glycosaminoglycan (Conti et al, 1989) have been studied in depressed demented subjects. However, these studies are graded by the APA experts' panel as either ".…”

mentioning

confidence: 99%

Treating Depression in Alzheimer's Disease: Integration of Differing Guidelines

Swartz

Barak

Mirecki

et al. 2000

Int. Psychogeriatr.

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Bnckground: The developments in the understanding of Alzheimer's disease (AD) have led to genetic testing, expansion of research centers, and emergence of novel treatment modalities. However, behavioral symptoms and disturbances remain the leading cause of distress to families and patients. The management of these disturbances is not fully elucidated and not without controversies. Aim: To review and integrate the two important approaches to management and treatment of depression in AD as published in the American Psychiatric Association's guidelines for the treatment of patients with AD versus the American Academy of Neurology's official publication on managing AD. Method: Both publications are analyzed focusing on the pharmacological treatment of depression. The analysis includes sources of data, generalization, and common and conflicting recommendations. Conclusion: Selective serotonin reuptake mhibitors are the drugs of choice for the treatment of depression in AD patients.

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“…Dietary supplements that contain tyrosine and/or phenylalanine lead to alertness and arousal. Methionine combines with ATP to produce S-adenosylmethionine (SAM), which facilitates the production of neurotransmitters in the brain [35][36][37][38]. Currently, more studies involving these neurochemicals are needed which exhibit the daily supplemental doses that should be consumed in order to achieve antidepressant effects.…”

Section: Major Depressionmentioning

confidence: 99%