The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review

Laurindo, Lucas Fornari; de Lima, Enzo Pereira; Laurindo, Lívia Fornari; Rodrigues, Victória Dogani; Chagas, Eduardo Federighi Baisi; de Alvares Goulart, Ricardo; Araújo, Adriano Cressoni; Guiguer, Elen Landgraf; Pomini, Karina Torres; Rici, Rose Eli Grassi; Maria, Durvanei Augusto; Direito, Rosa; Barbalho, Sandra Maria

doi:10.1016/j.phrs.2024.107430

Pharmacological Research

2024

DOI: 10.1016/j.phrs.2024.107430

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The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review

Lucas Fornari Laurindo,

Enzo Pereira de Lima,

Lívia Fornari Laurindo

et al.

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Cited by 2 publications

References 80 publications

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Isoorientin: Unveiling the hidden flavonoid's promise in combating cancer development and progression – A comprehensive review

Laurindo,

Pomini,

de Lima

et al. 2025

Life Sciences

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Isoorientin: Unveiling the hidden flavonoid's promise in combating cancer development and progression – A comprehensive review

Laurindo,

Pomini,

de Lima

et al. 2025

Life Sciences

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Fantastic Frogs and Where to Use Them: Unveiling the Hidden Cinobufagin’s Promise in Combating Lung Cancer Development and Progression Through a Systematic Review of Preclinical Evidence

Barbalho,

Torres Pomini,

Lima

et al. 2024

Cancers

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Cinobufagin (CB), a bufadienolide, has shown promising potential as an anticancer agent, particularly in combating lung cancer. This systematic review synthesizes preclinical evidence on CB’s effects against lung cancer, focusing on its mechanisms of action, efficacy, and potential clinical implications. We analyzed data from various preclinical studies involving both in vitro cell line models and in vivo animal models. The reviewed studies indicate that CB effectively reduces cell viability, induces apoptosis, and inhibits cell proliferation, migration, and invasion across multiple lung cancer cell lines and xenograft models. Specifically, CB was found to decrease cell viability and increase apoptosis in lung cancer cells by modulating key molecular pathways, including Bcl-2, Bax, cleaved caspases, caveolin-1, FLOT2, Akt, STAT3, and FOXO1. In vivo studies further demonstrated significant inhibition of tumor growth with minimal toxicity. However, limitations include reliance on in vitro models, which may not fully represent in vivo tumor dynamics, and a lack of long-term safety data. The studies also vary in their methodologies and cell line models, which may not accurately encompass all lung cancer subtypes or predict human responses. Despite these limitations, CB’s ability to target specific molecular pathways and its promising results in preclinical models suggest it could be a valuable addition to lung cancer treatment strategies. Our review suggests further clinical trials to validate its efficacy and safety in humans. Future research should explore combination therapies and optimize delivery methods to enhance clinical outcomes.

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The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review

Cited by 2 publications

References 80 publications

Isoorientin: Unveiling the hidden flavonoid's promise in combating cancer development and progression – A comprehensive review

Isoorientin: Unveiling the hidden flavonoid's promise in combating cancer development and progression – A comprehensive review

Fantastic Frogs and Where to Use Them: Unveiling the Hidden Cinobufagin’s Promise in Combating Lung Cancer Development and Progression Through a Systematic Review of Preclinical Evidence

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