The therapeutic potential of curcumin in alleviating N-diethylnitrosamine and iron nitrilotriacetate induced renal cell tumours in mice via inhibition of oxidative stress: Implications for cancer chemoprevention

Assessment of the Antitumor Activity of Green Biosynthesized Zinc Nanoparticles as Therapeutic Agent Against Renal Cancer in Rats

“…When rats were received Fe-NTA then treated with Zn-NPs, it was well-noticed that levels of MDA and DNA fragmentation were significantly decreased while the level of GSH, and the activities of SOD and GPx were significantly increased in Fe-NTA + Zn-NPs-treated rats when compared to Fe-NTA-treated rats, confirming the protective effect of Zn-NPs against the oxidative stress induced by Fe-NTA. In agreement to our findings, several studies reported that Fe-NTA enhance lipid peroxidation in kidney tissue by increasing thiobarbituric acid reactive substances such as MDA which is cytotoxic, damage the DNA leading to 8-hydroxy-2′-deoxyguanosine (8-OHdG) formation of which is mutagenic and carcinogenic leading to numerous functional changes in cells [ 31 – 33 ].…”

“…Fe-NTA is a potent nephrotoxic agent, causing renal adenocarcinoma in experimental rats when administrated for several times [ 29 ]. The mechanism by which Fe-NTA causes its effects seems mainly due to its ability to deplete the antioxidant battery and induce ROS generation by iron-catalyzed Fenton reaction, which in turn causing lipid peroxidation, and DNA damage [ 30 , 31 ]. This is consistent with our results as the level of MDA was significantly increased while the level of GSH and the activities of SOD and GPx were significantly decreased in Fe-NTA-treated rats when compared to controls.…”

Bioengineered Platforms for Detection Of Group-1 Carcinogenic Metals

“…Some of them are iron (Fe), copper (Cu), lead (Pb), and mercury (Hg), as listed by the International Agency for Research on Cancer (IARC) (Lay and Levina, 2013;Rousseau et al, 2005). High doses of iron and copper are carcinogenic, although they are well-controlled and often cause cancer only in animals or individuals with genetic conditions that impair metabolic regulation (Iqbal et al, 2021;Mandil et al, 2020). The phenomenon of cancer induction by metals and their role in environmental health concerns is still poorly understood, despite the growing number of research.…”

Maggot extracts chemo-prevent inflammation and tumorigenesis accompanied by changes in the intestinal microbiome and metabolome in AOM/DSS-induced mice

“…Anti-inflammatory treatment is very important and effective, so chemo-prevention strategies are necessary. Nowadays, food-origin and herb-origin products with diverse functions are emerged as novel chemo-prevention agents and are used in clinical medicine owing to their anti-inflammatory effects and safe benefits (Chung et al, 2018 ; Fong et al, 2020 ; Chen et al, 2021 ; Iqbal et al, 2021 ; Sameni et al, 2021 ). In addition, newer precision medicine, such as aspirin (acetylsalicylic acid), is placed with great hopes to get better control of the potential risks of cancerization (Gilligan et al, 2019 ; Hua et al, 2019 ).…”