The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

Tian, Fengwei; Yu, Leilei; Zhai, Qixiao; Xiao, Yue; Shi, Ying; Jiang, Jinchi; Liu, Xiaoming; Zhang, Hao; Chen, Wei

doi:10.1371/journal.pone.0175398

Cited by 22 publications

(13 citation statements)

References 52 publications

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“…However, supplementation with CAU 1447 or CAU 1447 cream cheese significantly prevented the increases in serum ALP, AST, and ALT levels caused by alcohol consumption. These results are supported by several previous studies demonstrating that treatment with some probiotics containing Lactobacillus spp., such as Lactobacillus brevis and Lactobacillus casei, and Bifidobacteria suppressed the upregulation of biomarkers or inflammatory factors related to alcoholic liver injury in patients and animal models (Segawa et al, 2008;Stadlbauer et al, 2008;Tian et al, 2017). Therefore, our results demonstrated decreases in ALP, AST, and ALT levels following supplementation with CAU 1447 or CAU 1447 cream cheese.…”

Section: Discussionmentioning

confidence: 50%

Hepatoprotective effects of Lactococcus chungangensis CAU 1447 in alcoholic liver disease

Nam

Kim

Konkit

et al. 2019

Journal of Dairy Science

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Alcoholic liver disease (ALD) is correlated with alcohol consumption, and ALD progression depends on various factors. Some lactic acid bacteria (LAB) are beneficial for mitigating ALD. However, the valuable effects of LAB-derived dairy products remain unclear. Here, we evaluated the effects of Lactococcus chungangensis CAU 1447 dry cells (CAU 1447) and cream cheese derived from CAU 1447 on ALD progression following long-term alcohol consumption in rats. Oral administration of CAU 1447 and CAU 1447 cream cheese significantly reduced alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and triglyceride levels. We found that CAU 1447 and CAU 1447 cream cheese downregulated mRNA encoding various cytokines and antioxidative factors in the liver. Oral CAU 1447 cream cheese administration increased short-chain fatty acid, butyrate, and acetate levels in feces. Thus, administration of CAU 1447 and CAU 1447 cream cheese induced hepatoprotective effects, indicating potential applications as a supplement for ALD mitigation.

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Section: Discussionmentioning

confidence: 50%

Hepatoprotective effects of Lactococcus chungangensis CAU 1447 in alcoholic liver disease

Nam

Kim

Konkit

et al. 2019

Journal of Dairy Science

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“…Recent studies have reported the beneficial protection of L. plantarum on stress-induced behavior dysfunction. Administration of living or dead L. plantarum improved cognitive deficits against aluminum-induced brain and liver injuries in mice [33] and attenuated anxiety behavior of stressed zebrafish [34]. Administration of L. plantarum MTCC 9510 reduced oxidative stress markers and inflammatory cytokines in the brain and serum and improved stress-induced behavioral despair [35].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice

Kim²,

2019

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Gut microbiota play a role in regulating mental disorders, but the mechanism by which gut microbiota regulate brain function remains unclear. Gram negative and positive gut bacteria release membrane-derived extracellular vesicles (EVs), which function in microbiota-host intercellular communication. In the present study, we investigated whether Lactobacillus plantarum derived EVs ( L -EVs) could have a role in regulating neuronal function and stress-induced depressive-like behaviors. HT22 cells treated with the stress hormone glucocorticoid (GC; corticosterone) had reduced expression of Bdnf and Sirt1 , whereas L -EV treatment reversed GC-induced decreased expression of Bdnf and Sirt1 . The siRNA-mediated knockdown of Sirt1 in HT22 cells decreased Bdnf4 , a splicing variant of Bdnf , and Creb expression, suggesting that Sirt1 plays a role in L -EV-induced increase of BDNF and CREB expression. Mice exposed to restraint for 2-h daily for 14 days (CRST) exhibited depressive-like behaviors, and these CRST-treated mice had reduced expression of Bdnf and Nt4/5 in the hippocampus. In contrast, L -EV injection prior to each restraint treatment blocked the reduced expression of Bdnf and Nt4/5 , and stress-induced depressive-like behaviors. Furthermore, L -EV treatment in CRST-treated mice also rescued the reduced expression of Bdnf , and blocked stress-induced depressive-like behaviors. These results suggest that Lactobacillus derived EVs can change the expression of neurotropic factors in the hippocampus and afford antidepressant-like effects in mice with stress-induced depression.

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“…brevis, were able to bind and remove toxic metals (Yu et al 2016). A recent study by Tian et al (2017) also suggests the potential of the Lb. plantarum strain to alleviate the aluminium-induced brain injuries in mice.…”

Section: Influence Of Lb Brevis Sf9b and Lb Plantarum Sf9c On Gut Mmentioning

confidence: 88%

Colonisation potential of plantaricin-producing Lactobacillus plantarum SF9C andS-layer-carrying Lactobacillus brevis SF9B among gut microbiota

Butorac¹,

Banić²,

Novak³

et al. 2020

Preprint

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Background: The influence of an S-layer-carrying strain Lactobacillus brevis SF9B and a plantaricin-producing strain Lactobacillus plantarum SF9C on the gut microbiota composition was evaluated in the rats. Considering the probiotic potential of Lb. brevis SF9B, this study aimed to examine the antibacterial activity of Lb. plantarum SF9C and potential for their in vivo colonisation, which could be the basis for the investigation of their synergistic functionality. Results: A plantaricin-encoding cluster was identified in Lb. plantarum SF9C, a strain which efficiently inhibited the growth of Listeria monocytogenes ATCC®19111™ and Staphylococcus aureus 3048. Contrary to the plantaricin-producing SF9C strain, the S-layer-carrying SF9B strain excluded Escherichia coli 3014 and Salmonella enterica serovar Typhimurium FP1 from adhesion to Caco-2 cells. Finally, DGGE analysis of the V2-V3 region of the 16S rRNA gene confirmed the transit of two selected lactobacilli through the gastrointestinal tract (GIT). Microbiome profiling via the Illumina MiSeq platform revealed the prevalence of Lactobacillus spp. in the gut microbiota of rats suggesting their colonisation potential in GIT.Conclusion: The combined application of Lb. plantarum SF9C and Lb. brevis SF9B could influence the intestinal microbiota composition, which is reflected through the increased abundance of Lactobacillus genus, but also through altered abundances of other bacterial genera, either in the model of healthy or aberrant microbiota of rats. The obtained results contributed to the functional aspects of SF9C and SF9B strains which could be incorporated in the probiotic-containing functional foods and therefore have a beneficial influence on the gut microbiota composition.

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The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

Cited by 22 publications

References 52 publications

Hepatoprotective effects of Lactococcus chungangensis CAU 1447 in alcoholic liver disease

Hepatoprotective effects of Lactococcus chungangensis CAU 1447 in alcoholic liver disease

Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice

Colonisation potential of plantaricin-producing Lactobacillus plantarum SF9C andS-layer-carrying Lactobacillus brevis SF9B among gut microbiota

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