The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin

A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport

“…Based on the efflux assay, all the results indicated that the different behaviors of intracellular uptake, even subcellular disposition in drug-sensitive and drug-resistant cells, might determine their therapeutic efficacy (Xiong et al, 2010). Then, Caco-2 cells and MDR1-MDCK cells were used to verify that DPT was not a substrate of these efflux transporters related to MDR.…”

Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells

“…The second possible explanation for the high cell-killing efficiency in the Micelle DOX was that the micellar particles are usually internalized inside cells by endocytosis, while free drugs mainly do this by diffusion. 28 Using the endocytosis mechanism to facilitate a cellular internalization has been widely reported in amphiphilic copolymers prepared by either block 25,29 or graft copolymerization, 12,13 which could increase drug availability in the cytoplasm. Optimizing the drug release from drug-encapsulated nanoparticles after entering inside cells is also a key factor to designing a successful drug delivery system.…”

Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system

“…An important breakthrough in this field is the preparation of a new class of nanosized DDS which can be internalized by tumor cells through the endocytosis pathway to avoid undesired drug release during drug transportation in blood circulation, thus improving effective release of the anticancer drug in tumor tissue or within tumor cells. 5 Furthermore, there has been growing interest in metal nanomaterials as anticancer drug carriers recently, which represents a promising approach to tumors, although it is still under investigation. 6,7 Barick et al reported a method for entrapping drugs at sites capable of complexing with transition metal ions and suggested that drug release is dependent on the pH of the medium and nature of the materials which encapsulate the drug.…”