The therapeutic value of bifidobacteria in cardiovascular disease

Abstract

There has been an increase in cardiovascular morbidity and mortality over the past few decades, making cardiovascular disease (CVD) the leading cause of death worldwide. However, the pathogenesis of CVD is multi-factorial, complex, and not fully understood. The gut microbiome has long been recognized to play a critical role in maintaining the physiological and metabolic health of the host. Recent scientific advances have provided evidence that alterations in the gut microbiome and its metabolites have a profound influence on the development and progression of CVD. Among the trillions of microorganisms in the gut, bifidobacteria, which, interestingly, were found through the literature to play a key role not only in regulating gut microbiota function and metabolism, but also in reducing classical risk factors for CVD (e.g., obesity, hyperlipidemia, diabetes) by suppressing oxidative stress, improving immunomodulation, and correcting lipid, glucose, and cholesterol metabolism. This review explores the direct and indirect effects of bifidobacteria on the development of CVD and highlights its potential therapeutic value in hypertension, atherosclerosis, myocardial infarction, and heart failure. By describing the key role of Bifidobacterium in the link between gut microbiology and CVD, we aim to provide a theoretical basis for improving the subsequent clinical applications of Bifidobacterium and for the development of Bifidobacterium nutritional products.

The interaction between oral microbiota and gut microbiota in atherosclerosis

“…Probiotics have great potential for treating various diseases by promoting nutrient absorption and regulating the balance of gut microbiota. Studies have found that the Bifidobacterium can inhibit the development of AS to a certain extent, so it is possible to treat AS by using probiotics to maintain the balance of gut microbiota ( 108 ). Prebiotics are a kind of organic matter that can provide nutrients to probiotics, promote their reproduction, and regulate the composition and function of microbiota.…”

The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases

“…Conversely, Anaerostipes exhibited decreased abundance compared to the control group [152]. HSD specifically affects the rodent gut microbiota by decreasing the abundance of Lactobacillus murinus and inducing T helper 17 cells, resulting in salt-sensitive hypertension [153]. Daily L. murinus supplementation ameliorates these effects [154].…”

Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation

“… 52 Bifidobacteriaceae is found to play a key role in suppressing oxidative stress, improving immunomodulation, and correcting lipid, glucose, and cholesterol metabolism. 53 However, whether early breastfeeding or fiber intake has CVDs linkage warrants further invastigations. Dietary habits also modulate the gut microbiota’s development and composition.…”