We extend the formalism of the thermodynamic two-time Green's functions to nonextensive quantum statistical mechanics. Working in the optimal Lagrangian multipliers representation, the q-spectral properties and the methods for a direct calculation of the two-time q-Green's functions and the related q-spectral density (q measures the nonextensivity degree) for two generic operators are presented in strict analogy with the extensive (q = 1) counterpart. Some emphasis is devoted to the nonextensive version of the less known spectral density method whose effectiveness in exploring equilibrium and transport properties of a wide variety of systems has been well established in conventional classical and quantum many-body physics. To check how both the equations of motion and the spectral density methods work to study the q-induced nonextensivity effects in nontrivial many-body problems, we focus on the equilibrium properties of a second-quantized model for a high-density Bose gas with strong attraction between particles for which exact results exist in extensive conditions. Remarkably, the contributions to several thermodynamic quantities of the q-induced nonextensivity close to the extensive regime are explicitly calculated in the lowtemperature regime by overcoming the calculation of the q grand-partition function.