2017
DOI: 10.15406/japlr.2017.05.00173
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The Thermodynamic Overlapping pKa of the Antitumor Drug Ibrutinib Using Multiwavelength UV/VIS-Spectroscopy and Potentiometry

Abstract: Potentiometric and spectrophotometric pH-titrations of the antitumor drug Ibrutinib for dissociation constants determination were compared. Ibrutinib is targeting B-cell malignancies, for treatment of chronic lymphocytic leukemia, and Waldenström's macroglobulinemia. Chemometrics approach to the nonlinear regression of the pH-spectra (REACTLAB, SQUAD84) and pH-titration (ESAB) determines four dissociation constants. Ibrutinib exhibits four protonatable centers in a pH range of 2 to 10, where only two pK are we… Show more

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Cited by 2 publications
(2 citation statements)
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“…Since most of the drugs are organic weak acids and/or bases, the pK a value gives information about the ionic form of the molecule over a wide pH value. [40] The pK a value of the IBR molecule has been reported as 3.74. [41][42] It can be expected that the protonated (cationic) form of IBR predominates in 0.1 mol L À 1 H 2 SO 4 , transforming IBR into an uncharged form in alkaline and weakly acidic solutions.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Since most of the drugs are organic weak acids and/or bases, the pK a value gives information about the ionic form of the molecule over a wide pH value. [40] The pK a value of the IBR molecule has been reported as 3.74. [41][42] It can be expected that the protonated (cationic) form of IBR predominates in 0.1 mol L À 1 H 2 SO 4 , transforming IBR into an uncharged form in alkaline and weakly acidic solutions.…”
Section: Resultsmentioning
confidence: 99%
“…This feature is vital in drug development. Since most of the drugs are organic weak acids and/or bases, the p K a value gives information about the ionic form of the molecule over a wide pH value [40] . The p K a value of the IBR molecule has been reported as 3.74 [41–42] .…”
Section: Resultsmentioning
confidence: 99%