The Thermoregulatory Threshold is Inversely Proportional to Isoflurane Concentration

Støen, Randi; Sessler, Daniel I.

doi:10.1097/00000542-199005000-00009

Cited by 133 publications

(44 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After induction, an esophageal temperature probe (Mon-a-therm, Mallincroft Medical, St. Louis, MO, USA) was placed at the distal end of the range of the maximal heart sound, where the esophageal temperature correlates well with the tympanic membrane temperature. 4 Tympanic membrane temperature was recorded again after extubation and in the recovery room.…”

Section: Me Et Th Ho Od Ds Smentioning

confidence: 99%

Intraoperative mild hypothermia does not increase the plasma concentration of stress hormones during neurosurgery

Z.¹,

Choi

Lee

et al. 2001

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

P Pu ur rp po os se e: : To determine how mild hypothermia (34°C) affects the hemodynamic and the stress hormonal responses intraoperatively and during extubation in patients undergoing cerebral aneurysm surgery.M Me et th ho od ds s: : After induction, anesthesia was maintained with 1.2% isoflurane and 50% nitrous oxide. For the normothermia and the hypothermia groups, the body temperature was maintained at 36.9 ± 0.3°C and 34.2 ± 0.2°C respectively up to the recovery room. Hemodynamic changes were recorded continuously. Stress hormones comprising epinephrine, norepinephrine, ADH, ACTH, and cortisol were measured at the awake control, intraoperative, and extubation periods.R Re es su ul lt ts s: : Vital signs of the intraoperative and postextubation time periods were not significantly different between the normothermia and hypothermia groups except for a statistically lower pulse rate intraoperatively in the hypothermia group (P <0.05). In the control awake state, all five hormonal concentrations were similar between the two groups. Intraoperatively, all of the hormonal levels tended to be lower in the hypothermia group compared to the normothermia group, but only the epinephrine level decreased sufficiently to reach statistical significance (P <0.05). During extubation, all stress hormone concentrations, except norepinephrine, were lower in the hypothermia group (epinephrine: P <0.05; ADH: P <0.05; ACTH: P <0.05; cortisol: P <0.05).C Co on nc cl lu us si io on ns s: : Our data suggest that intraoperative mild hypothermia neither significantly affects the blood pressure response nor increases the concentrations of stress hormones intraoperatively. Furthermore, mild hypothermia significantly decreased the plasma concentrations of stress hormones during the extubation period.

show abstract

Section: Me Et Th Ho Od Ds Smentioning

confidence: 99%

Intraoperative mild hypothermia does not increase the plasma concentration of stress hormones during neurosurgery

Z.¹,

Choi

Lee

et al. 2001

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

show abstract

“…General anesthesia decreases the thermoregulatory threshold for hypothermia by approximately 2.5~ and increases that for hyperthermia by about I~ [8]. The thermoregulatory threshold in halothane, enflurane, or fentanyl/N20 anesthesia is reportedly 34.5~ During isoflurane anesthesia, this threshold decreases about 3~ per percent of end-tidal concentration [9]. Although, a threshold change in sevoflurane anesthesia has not been reported, as far as we know, in our experience there were no special problems.…”

Section: Body Temperature Managementmentioning

confidence: 77%

Anesthetic management for a patient with oculocerebrorenal (Lowe's) syndrome

et al. 1994

View full text Add to dashboard Cite

“…In addition to volatile 10 and iv anesthetics including propofol, 11 a variety of anesthetic adjuvants 12,13 have been shown to impair thermoregulatory responses in humans. However, the effects of preanesthetic sedatives on perioperative hypothermia have not been ade- Values are expressed as the mean ± SD or absolute numbers.…”

Section: Discussionmentioning

confidence: 99%

L’administration im d’une prémédication de dropéridol atténue l’hypothermie peropératoire

Toyota

Sakura

Saito

et al. 2001

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

P Pu ur rp po os se e: : Perioperative hypothermia results largely from core-toperipheral heat redistribution. Droperidol, which is often used for premedication, promotes vasodilation, and thus may affect redistribution of heat. Accordingly, we tested the hypothesis that preanesthetic droperidol would affect perioperative hypothermia.M Me et th ho od ds s: : Twenty-three ASA physical status I patients scheduled for arthroscopic ligament reconstruction were randomly assigned to two groups to receive no premedication or im droperidol 0.1 mg·kg 1 30 min before anesthesia. Anesthesia was induced and maintained with propofol and fentanyl. We monitored core (tympanic) and peripheral (palm) temperatures, and skin (fingertip) blood flow for two hours after the induction of anesthesia during surgery.R Re es su ul lt ts s: : Before the induction of anesthesia, patients given droperidol were more deeply sedated than those given no premedication. Core temperature, which was similar in both groups before induction, decreased significantly more in the control than in the droperidol patients (0.75 ± 0.34°C and 0.37 ± 0.20°C, respectively, at 75 min after induction; P <0.01). Preinduction peripheral temperature and skin blood flow were lower in the control group than in the droperidol group, but the two variables became similar in both groups after induction. C Co on nc cl lu us si io on n: : The results of the present study confirm our hypothesis that premedication with droperidol affects perioperative hypothermia. Droperidol may prevent core-to-peripheral heat redistribution after the induction of anesthesia.

show abstract

The Thermoregulatory Threshold is Inversely Proportional to Isoflurane Concentration

Cited by 133 publications

References 0 publications

Intraoperative mild hypothermia does not increase the plasma concentration of stress hormones during neurosurgery

Intraoperative mild hypothermia does not increase the plasma concentration of stress hormones during neurosurgery

Anesthetic management for a patient with oculocerebrorenal (Lowe's) syndrome

L’administration im d’une prémédication de dropéridol atténue l’hypothermie peropératoire

Contact Info

Product

Resources

About