The three-dimensional genome in zebrafish development

Abstract

In recent years, remarkable progress has been made toward understanding the three-dimensional (3D) organisation of genomes and the influence of genome organisation on gene regulation. Although 3D genome organisation probably plays a crucial role in embryo development, animal studies addressing the developmental roles of chromosome topology are only just starting to emerge. Zebrafish, an important model system for early development, have already contributed important advances in understanding the developmental consequences of perturbation in 3D genome organisation. Zebrafish have been used to determine the effects of mutations in proteins responsible for 3D genome organisation: cohesin and CTCF. In this review, we highlight research to date from zebrafish that has provided insight into how 3D genome organisation contributes to tissue-specific gene regulation and embryo development.

Epigenetic disorders: Lessons from the animals–animal models in chromatinopathies

“…It can be exploited for a deep characterization of disorders involving embryogenesis, due to its transparent embryos and larvae, and it represents a valid model for studying organs and structures shared with humans ( Santoriello and Zon, 2012 ). For example, this model has been used to evaluate 3D genome organization of the epigenetic machinery ( Labudina and Horsfield, 2021 ).…”