The Threshold Effects of Low-Dose-Rate Radiation on miRNA-Mediated Neurodevelopment of Zebrafish

He, Chuqi; Mao, Liang; Ye, Jin; Zhao, Weichao; Huang, Bo; Hu, Nan; Long, Dongyang

doi:10.1667/rade-20-00265.1

Cited by 4 publications

(1 citation statement)

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“…From a genetic perspective, miRNAs were involved in cell proliferation, differentiation, and apoptosis and affect the development and maturation of the brain and extensively regulate neuroendocrine processes. 43 , 44 At the same time, personality disorder and schizophrenia are closely related to brain development and neuroendocrine. 45 , 46 The results indicated that miRNA may be involved in the pathophysiological process of both personality disorder and schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

The Correlation Between Peripheral Blood MicroRibonucleic Acid Expression Level and Personality Disorder in Patients with Schizophrenia

Wei,

Kong,

Zhu

et al. 2024

ALPHA PSYCHIATRY

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Objective: Schizophrenia patients often have personality disorders; schizophrenia patients with personality disorders are more difficult to treat and have a worse prognosis. Early identification of this group of patients and early intervention can achieve better prognosis. Therefore, it is very important to explore effective biomarkers and early diagnosis for the prognosis of schizophrenia. The primary purpose of this paper is to explore the relationship between plasma miRNA expression level and personality disorder with schizophrenia. Methods: Gene microarrays in miRNA files were employed, and the plasma of peripheral blood of 82 schizophrenic patients and 43 healthy control subjects were examined. Real-time reverse transcription polymerase chain reaction detection were performed to explore the results. Spearman correlation analysis was used to analyze the correlation between expression level of miRNAs and Personality Diagnosis Questionnaire-4 score. Results: The results showed that miR-1273d, miR-1303, miR-3064-5p, miR-3131, miR-3687, miR-4428, miR-4725-3p, and miR-5096 were up-regulated in schizophrenic patients. Compared to healthy control subjects, the difference was statistically significant ( P < .05). Schizophrenic patients with schizoid, paranoid, schizotypal, and obsessive compulsive traits had negative correlation with miR-1303, miR-3131, miR-4428, and miR-5096 expression level ( r = −0.40 to −0.62, P < .05); there were no significant differences in the other miRNAs. Correlation with other personality traits was not significant ( P > .05). The stepwise regression analysis indicated that miR-5096, miR-3131, and miR-1273d have a significant predictive effect on the schizoid trait ( P < .01). MiR-4428 and miR-1303 had a significant predictive effect on the schizotypal trait ( P < .01). MiR-5096, miR-4428, and miR-4725-3P had a significant predictive effect on the paranoid trait ( P < .05). MiR-4428, miR-1303, and miR-5096 had a significant predictive effect on the obsessive compulsive trait ( P < .05). Conclusion: The expression levels of miR-1273d, miR-1303, miR-3064-5p, miR-3131, miR-3687, miR-4428, miR-4725-3p, and miR-5096 were up-regulated in the peripheral blood of patients with schizophrenia, and these miRNAs are expected to be diagnostic biomarkers for accurate diagnosis of schizophrenia. The expression levels of miR-1303, miR-3131, miR-1273d, miR-4428, miR-4725-3p, and miR-5096 have significant predictive effects on personality disorder in schizophrenia.

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