The thymus and skin wound healing in Xenopus laevis adults

Franchini, Antonella; Bertolotti, Evelina

doi:10.1016/j.acthis.2014.05.009

Cited by 10 publications

(20 citation statements)

References 37 publications

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“…That immune and inflammatory mechanisms are the master regulators of tissue repair and fibrosis is suggested by studies in which lower vertebrates utilize scarless repair and regeneration or, alternatively, fibrosis, depending on immune and inflammatory cell engagement [59][60][61][62][63]. Finally, wide-ranging research over the past few decades into possible immune and inflammatory causes of fibrosis has led to identification of several major functional families of molecules that are undoubtedly pro-or antifibrotic.…”

Section: Resident Tissue Cells Fibroblasts Epithelial Cells (Emt) Endmentioning

confidence: 96%

The cytokines of pulmonary fibrosis: Much learned, much more to learn

et al. 2015

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Section: Resident Tissue Cells Fibroblasts Epithelial Cells (Emt) Endmentioning

confidence: 96%

The cytokines of pulmonary fibrosis: Much learned, much more to learn

et al. 2015

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“…A benefit to using Xenopus as a model is that they are able to regenerate skin appendages, such as exocrine glands. Additionally, Xenopus have a multi-layered epidermis, similar to that of mammals (Bertolotti et al, 2013; Caddy et al, 2010; Franchini and Bertolotti, 2014; Franchini et al, 2016; Otsuka-Yamaguchi et al, 2017; Yoshii et al, 2005). Just like frogs, urodele amphibians, such as newts and axolotls, also have the ability to regenerate skin appendages scar-free (Fig.…”

Section: Scar-free Regeneration: Learning From Animals With the Namentioning

confidence: 99%

“…is immunosuppressed during the refractory period, the regenerative ability is restored (Fukazawa et al, 2009). During the refractory period, it has also been shown that there is an increase in the amount of immune cells that traffic to the wound area, suggesting that there may be an increased immune response during this time (Franchini and Bertolotti, 2014). Several studies in Xenopus spp.…”

Section: Common Traits Of Scar-free Wound Healingmentioning

confidence: 99%

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Erickson

Echeverri

2018

Developmental Biology

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The skin is the largest organ in the body and plays multiple essential roles ranging from regulating temperature, preventing infection and ultimately defining who we are physically. It is a highly dynamic organ that constantly replaces the outermost cells throughout life. However, when faced with a major injury, human skin cannot restore a significant lesion to its original functionality, instead a reparative scar is formed. In contrast to this, many other species have the unique ability to regenerate full thickness skin without formation of scar tissue. Here we review recent advances in the field that shed light on how the skin cells in regenerative species react to injury to prevent scar formation versus scar forming humans.

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“…A stimulation in its activity, associated with infiltration of T‐lymphocytes into the provisional wound matrix, was indicated. (Franchini and Bertolotti, ). In contrast, the decline of regenerative potential to form a new, complete and correctly patterned tail in tadpoles undergoing metamorphosis was correlated to an impairment in thymic function (Franchini and Bertolotti, ).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, the decline of regenerative potential to form a new, complete and correctly patterned tail in tadpoles undergoing metamorphosis was correlated to an impairment in thymic function (Franchini and Bertolotti, ). The findings suggest that distinct pathways and mechanisms could be involved in the decline of regenerative potential during Xenopus development (Franchini and Bertolotti, ). To clarify the role of fully mature adaptive immunity in cutaneous wound healing, we examined structural and molecular responses occurring in the spleen of 15 month X. laevis .…”

Section: Introductionmentioning

confidence: 99%

The spleen and skin wound healing in Xenopus adults

Franchini

Rocca

Bertolotti

2016

Journal of Morphology

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In most vertebrates, the regenerative capacity to restore lost/damage tissues to original structure and functionality decreases at some time during ontogenesis. To evaluate the role of the acquired immunity in the decline of regenerative potential, we examined the cellular responses elicited in the spleen during skin repair in Xenopus adults. Modifications in the architecture were found to be induced and were remarkable 14 days postinjury when the spleen increased significantly in size. In white pulp, the periarteriolar lymphoid sheaths were associated with follicles having central light zones, morphologically similar to germinal centers. With the progress of healing, pigment-containing cells were seen to accumulate in both white and red pulp regions. Moreover, compared to controls, the cells immunoreactive to anti-cytokines (TNF-α, TGF-β1) and -iNOS increased from the first days after wounding. The 14th day, the positive cells formed a dense network of reticular cells in central regions of lymphoid follicles and more frequent reactive leukocytes were detected within the red pulp. A higher number of lymphoid cells immunostained with anti-CD3ε were also observed in the perifollicular zone. The results suggest that the spleen of adult frogs is involved in skin wound healing with the expansion of lymphoid compartments. J. Morphol. 277:888-895, 2016. © 2016 Wiley Periodicals, Inc.

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The thymus and skin wound healing in Xenopus laevis adults

Cited by 10 publications

References 37 publications

The cytokines of pulmonary fibrosis: Much learned, much more to learn

The cytokines of pulmonary fibrosis: Much learned, much more to learn

Learning from regeneration research organisms: The circuitous road to scar free wound healing

The spleen and skin wound healing in Xenopus adults

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