The Thyroid

Werner, S C; Nauman, J A

doi:10.1146/annurev.ph.30.030168.001241

Cited by 30 publications

(19 citation statements)

References 86 publications

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“…It has also been proposed that thyroid hormone may possibly regulate energy conservation in mitochondria (27) and Nishiki et al (28) showed that both cytochrome and mitochondrial proteins were increased in hyperthyroid rat hearts in relation to wet weight. Others Thyroid activity increases progressively during late gestation, but within a few days prior to birth, there is a marked increase in plasma T3 concentrations to levels similar to those we recorded immediately prior to delivery in Groups I and III animals.…”

Section: Discussionmentioning

confidence: 99%

Role of thyroid hormone in postnatal circulatory and metabolic adjustments.

1984

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At bstract. To assess the role of the early postnatal surge in plasma thyroid hormone concentrations on cardiovascular and metabolic adaptations, we measured cardiac output, total oxygen consumption, and plasma triiodothyronine (T3) concentrations in three groups of lambs in the first 6 h after delivery. 15 fetal lambs were prepared at gestational ages of 128-129 d by placing catheters in the brachiocephalic artery, descending aorta, distal inferior vena cava, left atrium, and pulmonary artery so that measurements could be made soon after delivery. They were divided into three groups: Group I comprised five control animals; Group II consisted of five fetuses in which thyroidectomy was performed at surgery at 129 d gestation; and Group III consisted of five animals in which thyroidectomy was performed at term gestation during delivery by caesarian section, prior to severing the umbilical cord. The lambs in Group I exhibited a rapid postnatal rise in T3 concentrations, similar to that described previously, reaching a peak value of about 5 ng/ml. Although the postnatal surge in T3 concentration was arrested in Group II and III animals, Group II had no detectable plasma T3, while the Group III animals had T3 concentrations of about 0.8 ng/ml, which were within the range previously reported for term lamb fetuses. The lambs in group II showed 40-50% lower left ventricular outputs (190 vs. 297 lambs in Group II also had significantly lower heart rates (131 vs. 192 beats/min) and mean systemic arterial pressures (56 vs. 72 torr). However, there were no significant differences for any of these measurements between the Group III and Group I lambs. The reduction in cardiac output in the Group II animals were reflected in a significantly lower blood flow to the peripheral circulation, but there were no significant differences in blood flow to other organs in the three groups. These studies indicate that plasma thyroid concentrations in the 2-3 wk prior to delivery and not the increase in thyroid hormone concentrations which occur after birth are important for postnatal cardiovascular and metabolic adjustments. We speculate that lack of circulating triiodothyronine in late gestation may affect postnatal cardiovascular adaptation by modifying normal beta adrenergic receptor development.

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Section: Discussionmentioning

confidence: 99%

Role of thyroid hormone in postnatal circulatory and metabolic adjustments.

1984

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“…The biochemical mechanism of thyroid hormones has been extensively investigated (17)(18)(19), and in general the conclusion is that the transformation of energy derived from oxidative reactions into metabolically utilizable phosphate bonds (e.g., ATP) is altered. The present authors are proposing a mechanism of action of thyroid hormones in the human erythrocytes which involves the indirect hydrolysis of 1,3-DPG via 2,3-DPG to 3-PG.…”

Section: Methodsmentioning

confidence: 99%

Mechanism of action of thyroid hormones on erythrocyte 2,3-diphosphoglyceric acid synthesis

Snyder¹,

Reddy²

1970

J. Clin. Invest.

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“…The 2nd patient, a 3-year-old girl with apparently mild hypothyroidism and no goiter, was diagnosed as having a coupling defect on the basis of elevated monoiodotyrosine levels and decreased levels of other iodothyronines [ 121. This would appear to be insufficient information for diagnosis of a constellation that may not be the result of a specific defect [13].…”

Section: Discussionmentioning

confidence: 99%

Graves disease in a patient with the del(18p) syndrome

1982

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We report the first known patient with a del(18p) and Graves disease. This deletion has previously been reported to be associated with autoimmune thyroid disease and, perhaps, with inborn errors of thyroxin biosynthesis. We present the clinical and histological information on this patient and review the literature in an attempt to clarify the relationship between abnormalities of chromosome 18 and thyroid disease.

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The Thyroid

Cited by 30 publications

References 86 publications

Role of thyroid hormone in postnatal circulatory and metabolic adjustments.

Role of thyroid hormone in postnatal circulatory and metabolic adjustments.

Mechanism of action of thyroid hormones on erythrocyte 2,3-diphosphoglyceric acid synthesis

Graves disease in a patient with the del(18p) syndrome

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