The thyrotropin-releasing hormone test in depressed and non-depressed psychiatric patients

Maes, Michaël; Hobin, Paul; Ruyter, Marcel De; Suy, E.

doi:10.1017/s0767399x0000225x

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…Deze significante discriminatie van beide depressieve toestandsbeelden berust ten dele op de ernst van de depressie: een melancholie is een ernstiger ziekte dan de andere depressieve groepen, terwijl ook een negatief verband tussen het TSH-antwoord en de ernst van de ziekte is vastgesteld (een negatieve correlatie met de Hamilton Depressie Score). 16 ' 17 ' 19 SPECIFICITEIT VAN DE TRH-TEST…”

Section: De Trh-test En Depressieunclassified

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The TRH-test in depression: a review

Christiaens¹,

Maes²

1994

Acta Neuropsychiatr.

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The TRH-test in depression: a review This paper reviews the literature on the thyrotropin releasing hormone (TRH)-test in depressive patients. The TRH-test appears to exhibit some use as an external validating criterion for the clinical diagnosis of major depression and, in particular melancholia versus minor depression once the clinical diagnosis depression is made. However, the clinical use of this test is hampered by the low sensitivity (±50%) and by the fact that abnormal tests occur in non-depressive states such as borderline personality disorder, schizophrenia, and anxiety disorders. The TRH-test may be used as a predictor for a positive response to biological therapies. In addition, the test has some value for the outcome of a depressive episode. The pathophysiology underpinning an abnormal TRH-test may be determined by noradrenergic (central and peripheric) or serotonergic (central) dysfunctions, thyroid hormone and cortisol hypersecretion, phenomena that are pertinent to severe depression. Recently, it has been established that an abnormal depression-linked TRH-test reflects lower basal thyroid secreting hormone (TSH) secretion. The determination of basal TSH may, in the future, replace TRH-testing.

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Section: De Trh-test En Depressieunclassified

“…Dit wordt schematisch geillustreerd in figuur 1. Uit onze ervaring blijkt nochtans dat zelf bij gecombineerd gebruik van beide tests de sensitiviteit te laag is om echt klinisch bruikbaar te zijn 16.…”

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The TRH-test in depression: a review

Christiaens¹,

Maes²

1994

Acta Neuropsychiatr.

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“…The test consists of TRH administration, and determination of peak and baseline (threshold) levels of blood TSH. Age, sex, metabolic and thyroid status, treatment, and depressive characteristics may influence test results (Extein et al, 1982;Loosen eta/, 1982;Baumgartcn et al, 1985;Maes et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

“…The stimulating dose of TRH is difficult to determine. Authors have used from 200 (Kirkegaard et al, 1978;Maes et al, 1988); to 550 fig TRH, and Masturzo et al (1988) have demonstrated the influence of dose variation.…”

Section: Introductionmentioning

confidence: 99%

The thyrotropin-releasing hormone test: some statistical considerations

Lima¹,

Vandel

Bizouard

1992

Eur. psychiatr.

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SummaryFinal conclusions and data comparisons from the thyrotropin-releasing hormone (TRH) test results are made difficult by differences in test implementation methods, ie, TRH different administration routes, dosages and blood sampling times. A number of statistical analyses are feasible, which may also influence test interpretation. The authors review some types of statistical analyses and suggest using the area under curve (AUC) method as a means of evaluation. The TRH test was performed before treatment and after a 5-day wash-out period, in 40 depressed patients hospitalized in the Psychiatric Unit of Besancon Teaching Hospital (Centre Hospitalier Universitaire de Besançon). Variation analyses performed by peak and threshold comparison (7.0 IµU/ml) and by the AUC method (386 IµU/ml) in positive and negative patients revealed some statistical differences.

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The periodicities in and biometeorological relationships with bed occupancy of an acute psychiatric ward in Antwerp, Belgium

et al. 1993

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Recently, some investigators have established a seasonal pattern in normal human psychology, physiology and behaviour, and in the incidence of psychiatric psychopathology. In an attempt to elucidate the chronopsy and meteotropism in the latter, we have examined the chronograms of, and the biometeorological relationships to bed occupancy of the psychiatric ward of the Antwerp University Hospital during three consecutive calendar years (1987-1989). Weather data for the vicinity were provided by a local meteorological station and comprise mean atmospheric pressure, air temperature, relative humidity, wind speed and minutes of sunlight and precipitation/day. The number of psychiatric beds occupied during the study period exhibited a significant seasonal variation. Peaks in bed occupancy were observed in March and November, with lows in August. An important part of the variability in the number of beds occupied could be explained by the composite effects of weather variables of the preceding weeks. Our results suggest that short-term fluctuations in atmospheric activity may dictate some of the periodicities in psychiatric psychopathology.

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The thyrotropin-releasing hormone test in depressed and non-depressed psychiatric patients

Cited by 9 publications

References 32 publications

The TRH-test in depression: a review

The TRH-test in depression: a review

The thyrotropin-releasing hormone test: some statistical considerations

The periodicities in and biometeorological relationships with bed occupancy of an acute psychiatric ward in Antwerp, Belgium

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