The Time Course of Haemodynamic, Autonomic and Skeletal Muscle Metabolic Abnormalities Following First Extensive Myocardial Infarction in Man

Effects of exercise training modality on skeletal muscle fatigue in men with coronary heart disease

“…A possible explanation for an improved exercise tolerance in the combined aerobic and resistance group may be the increases in leg strength in this group, allowing patients to reach higher level of oxygen uptake during cycling. Magnetic resonance spectroscopy studies have shown reduced muscle oxidative capacity in CHD and CHF patients during exercise (Adamopoulos et al, 1999;Cottin et al, 1996), and that training improves skeletal oxidative metabolism in these same populations (Ades et al, 1996;Cottin et al, 1996;Ohtsubo et al, 1997). The improvements witnessed in VO 2 at ventilatory threshold (close to significativity for peak VO 2 , p = 0.08) in the combined aerobic and resistance group may in part be the result of improved skeletal muscle metabolism.…”

Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction

“…Parasympathetic tone is already reduced on the day of the infarction [19,20], but may recover over a period varying from several days [19,20] to months [21][22][23][24], except in patients who subsequently develop heart failure [25]. The degree of withdrawal of parasympathetic activity following a myocardial infarction depends on the size and location of the infarcted region [26,27], and the ensuing degree of LV dysfunction [8].…”

Atorvastatin therapy improves exercise oxygen uptake kinetics in post‐myocardial infarction patients

“…Exercise intolerance and reduced oxygen uptake (VO 2 ) are established features of the clinical picture of post-myocardial infarction (MI) patients [12,13]. Measuring the gas exchange response to exercise, Koike and co-workers [14] have reported that VO 2 kinetics during submaximal exercise is decreased in these patients.…”