The Time-Dependent Clearance of VirulentTreponema pallidumin Susceptible and Resistant Strains of Guinea Pigs Is Significantly Different

Wicher, Victoria; Wicher, Konrad; Abbruscato, Frank; Auger, Ivan E.; Rudofsky, Ulrich H.

doi:10.1006/clim.1998.4672

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Consequently, the natural rabbit model has been used to investigate pathogenesis and immunity of human syphilis or to develop therapeutic approaches (Morgan et al, 2002;Peng et al, 2015;Tantalo et al, 2005). The guinea pig model has also been used to study the pathogenesis and the development of the adaptive immune response to T. pallidum (Wicher et al, 1999). Other animal models such as guinea…”

Section: Treponema Pallidummentioning

confidence: 99%

Contribution of the swine model in the study of human sexually transmitted infections

Käser

Renois

Wilson

et al. 2018

Infection, Genetics and Evolution

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The pig has garnered more and more interest as a model animal to study various conditions in humans. The growing success of the pig as an experimental animal model is explained by its similarities with humans in terms of anatomy, genetics, immunology, and physiology, by their manageable behavior and size, and by the general public acceptance of using pigs for experimental purposes. In addition, the immunological toolbox of pigs has grown substantially in the last decade. This development led to a boost in the use of pigs as a preclinical model for various human infections including sexually transmitted diseases (STIs) like Chlamydia trachomatis. In the current review, we discuss the use of animal models for biomedical research on the major human STIs. We summarize results obtained in the most common animal models and focus on the contributions of the pig model towards the understanding of pathogenesis and the host immune response. In addition, we present the main features of the porcine model that are particularly relevant for the study of pathogens affecting human female and male genital tracts. We also inform on the technological advancements in the porcine toolbox to facilitate new discoveries in this biologically important animal model. There is a continued need for improvements in animal modeling for biomedical research inclusive STI research. With all its advantages and the highly improved toolbox, the porcine model can play a crucial role in STI research and open the door to new exciting discoveries.

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Section: Treponema Pallidummentioning

confidence: 99%

Contribution of the swine model in the study of human sexually transmitted infections

Käser

Renois

Wilson

et al. 2018

Infection, Genetics and Evolution

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“…Unlike RIT, PCR cannot distinguish between living and dead treponemes. However, at least in laboratory animals, dead treponemes are eliminated in 2-4 weeks [19], and in animal models, the strong correlation between RIT and PCR suggests that positive PCR represents a true detection of living organisms [22]. Freeze-thawing cycles and storage at room temperature does not interfere with the ability to detect the treponemal DNA using PCR [23].…”

Section: Limitations Of Present Laboratory Tests For Syphilismentioning

confidence: 99%

Diagnosis of syphilis by polymerase chain reaction and molecular typing of Treponema pallidum

Šmajs¹,

Matějková²,

Woznicová³

et al. 2006

Reviews in Medical Microbiology

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“…C3 knockout mice challenged with group B streptococci or with Streptococcus pneumoniae display a significant impairment in defense against these organisms (71,72). Clearance of Treponema pallidum is also significantly slower in C4-deficient guinea pigs (73).…”

Section: Host Defensesmentioning

confidence: 99%

Complement: a critical test of its biological importance

Schmidt

Colten

2000

Immunological Reviews

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The biological activities of the more than 30 proteins that comprise the complement system have been elucidated in parallel lines of investigation that resulted in the purification of the proteins and studies of their function in vitro. Twenty years ago, the first complement cDNA clones were generated. Subsequently the structure and chromosomal localization of the complement genes and the primary sequences of their gene products were revealed. For some, even their higher order structure was solved. This work, coupled with studies of complement gene expression, biosynthesis, post-synthetic processing and secretion, contributed to an analysis of the relatively rare naturally occurring genetic deficiencies of complement proteins discovered fortuitously in humans sand experimental animals. Not until the past 5 years, with the application of methods for manipulating genes in vivo (targeted deletion and overexpression), has it been possible to definitively assign specific functions to complement proteins and to assess their importance in the intact organism. These relatively recent studies have confirmed the in vitro work or revealed unexpected roles for complement effector and regulatory proteins in host defenses, specific immunity, immunopathology, metabolism and reproductive biology This work is reviewed and the implications for understanding human diseases and the design of novel pharmaceutical agents are discussed. The promise of this line of investigation is certain but the context imposed by gender, developmental stage, other genes and environment must be taken into account before the practical implications of this deeper understanding of complement biology are fully realized.

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The Time-Dependent Clearance of VirulentTreponema pallidumin Susceptible and Resistant Strains of Guinea Pigs Is Significantly Different

Cited by 4 publications

References 35 publications

Contribution of the swine model in the study of human sexually transmitted infections

Contribution of the swine model in the study of human sexually transmitted infections

Diagnosis of syphilis by polymerase chain reaction and molecular typing of Treponema pallidum

Complement: a critical test of its biological importance

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