The Time of Esophagogastrodudenoscopy in Relation to Examination Quality Measures

Romańczyk, Marcin; Romańczyk, Tomasz; Lesińska, Magdalena; Barański, Kamil; Hartleb, Marek; Waluga, Marek

doi:10.1055/s-0040-1704619

Cited by 2 publications

(3 citation statements)

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“…The reasons for the lack of isomerization of the O-protomer to N-protomer during ISCAD and MCAD needs to be addressed. In both of these experiments, the kinetic energies of the ions were greater, the time frame was shorter (μs vs ms time frame), and for ISCAD, the pressure was lower than in ITCAD, 24 which hinder the formation of large, long-lived solvent clusters. Furthermore, the MCAD cell did not contain water as it was located far away from the atmospheric pressure ionization source and it was filled with high-purity nitrogen gas.…”

Section: ■ Experimental Sectionmentioning

confidence: 96%

“…20,21 The accelerated ions (with 13 eV kinetic energy) underwent activating collisions with nitrogen gas (Indiana Oxygen, purity 99.998%) at a nominal pressure of 3−5 mTorr in the octupole 22 for a very short time period (μs time frame). 23,24 All ions were then transferred through the C-trap into the high-resolution orbitrap for detection and analysis.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Effects of Residual Water in a Linear Quadrupole Ion Trap on the Protonation Sites of 4-Aminobenzoic Acid

Yerabolu

Kenttämaa

2019

J. Am. Soc. Mass Spectrom.

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In solution, the most basic site in 4-aminobenzoic acid is the amino nitrogen, while the carboxylic acid oxygen is the most basic site in the gas phase. However, the protonation site in the gas phase has been demonstrated to depend on the ionization solvents when ionized using positive ion mode electrospray ionization (ESI). In many of these studies, collision-activated dissociation (CAD) was used to differentiate the protomers. To explore the influence of different CAD conditions on the manifested protonation site, 4-aminobenzoic acid dissolved either in 1:1 acetonitrile−water or 3:1 methanol−water was ionized by ESI and subjected to three different CAD experiments in a linear quadrupole ion trap/orbitrap mass spectrometer. Based on in-source CAD (ISCAD) and beam-type medium-energy CAD (MCAD), the proton resided on the nitrogen atom (N-protomer) when acetonitrile−water was used as the solvent system but on the oxygen atom (O-protomer) when methanol−water was used. Interestingly, a predominant Nprotomer was observed when CAD was performed in the linear quadrupole ion trap (ITCAD), irrespective of the solvents used, in disagreement with literature. This unexpected result is rationalized based on the formation of long-lived water clusters of varying sizes for the protomers in the quadrupole ion trap due to residual water, low ion kinetic energies, long ion storage times, and relatively high pressure. Further, addition of extra water into the quadrupole ion trap resulted in nearly identical protomer distributions for both protomers. Therefore, this distribution must be near the equilibrium distribution caused by the presence of water clusters of varying sizes, some favoring the N-protomer and others the O-protomer.

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Section: ■ Experimental Sectionmentioning

confidence: 96%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Effects of Residual Water in a Linear Quadrupole Ion Trap on the Protonation Sites of 4-Aminobenzoic Acid

Yerabolu

Kenttämaa

2019

J. Am. Soc. Mass Spectrom.

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show abstract

“…The agreement on adequate vs inadequate cleanliness was similar among the Western and Eastern experts (Western: 0.74; 95% CI 0.64 – 0.84 and Eastern: 0.70; 95% CI 0.55 – 0.85) being substantial in both cases. 1…”

mentioning

confidence: 99%

International validation of a PEACE scale assessing cleanliness during esophagogastroduodenoscopy to improve the quality of inspection during endoscopy

Romańczyk,

Desai,

Kaminski

et al. 2024

ESGE Days 2024

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The Time of Esophagogastrodudenoscopy in Relation to Examination Quality Measures

Cited by 2 publications

References 0 publications

Effects of Residual Water in a Linear Quadrupole Ion Trap on the Protonation Sites of 4-Aminobenzoic Acid

Effects of Residual Water in a Linear Quadrupole Ion Trap on the Protonation Sites of 4-Aminobenzoic Acid

International validation of a PEACE scale assessing cleanliness during esophagogastroduodenoscopy to improve the quality of inspection during endoscopy

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