The time of palatal fusion in mice: a factor of strain susceptibility to teratogens

Syska, E.; Schmidt, Reiner; Schubert, Johannes

doi:10.1016/j.jcms.2003.09.003

Cited by 15 publications

(20 citation statements)

References 17 publications

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“…For example, macrophage activation decreases incidence of cleft palate and digital and tail anomalies in fetuses of mice that received urethane and methylnitrous urea (Holladay et al, 2000). Interferon gamma reduces urethane-induced cleft palate and granulocyte-colony stimulating factor decreases cyclophosphamide -induced distal limb abnormalities in mice (Syska et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Prophylactic Effects of Melatonin on Sodium Valproate-Induced Neural Tube Defects and Skeletal Malformations in Rat Embryos

Rahgazar¹,

Ranjbar²,

Varzi³

et al. 2011

American Journal of Applied Sciences

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Problem statement: Some reports showed the teratogenic effects of sodium valproate can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin on teratogenic effects of sodium valproate was compared. Approach: This study was performed on 31 pregnant rats that were divided into five groups. Control group received normal saline and test groups received sodium valproate (300 mg kg ), intraperitonealy at 8-9th days of gestation, respectively. Fetuses were collected at 20th day of gestation and after determination of weight and length; they were stained by Alizarin red-Alcian blue method. Results: Cleft palate, spina bifida and exencephaly incidence were 17.70, 20 and 20% in fetuses of rats that received only sodium valproate. Cleft palate, spina bifida and exencephaly incidence were 4.16, 8.33 and 8.33% range in group which received sodium valproate plus melatonin (5 mg kg −1 ), respectively. However, Cleft palate, spina bifida and excencaphaly incidence were 4/76, 0 and 0% in group which received sodium valproate plus melatonin (10 mg kg −1 ), respectively. The mean of weight and length of animals' fetuses that received melatonin were significantly greater than those received only sodium valproate. Conclusion: It is concluded that melatonin with dose of 10 mg kg −1 had significantly more prophylactic effect than melatonin with dose of 5 mg kg −1 on incidence of sodium valproate-induced skeletal malformations.

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Section: Introductionmentioning

confidence: 99%

Prophylactic Effects of Melatonin on Sodium Valproate-Induced Neural Tube Defects and Skeletal Malformations in Rat Embryos

Rahgazar¹,

Ranjbar²,

Varzi³

et al. 2011

American Journal of Applied Sciences

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“…The mouse model is well-established 7,12,29 . The development of the palatal shelves in the mouse during the early foetal period in organogenesis 8,13,15,21 has been studied and this animal model allows the study of normal and cleft palatogenesis 12,14,24 . The advantage of the mouse model is the easy transferability of the main features of palatogenesis and palatal development to human palatal development 4,5,10,11 .…”

mentioning

confidence: 99%

“…Normal secondary palatal development in the mouse begins on the twelfth day of gestation (12.5 GD) in the late embryonic/ early foetal period 2,13,24 . The palatal shelves are raised from the maxillary processes and consist mainly of mesenchymal tissue, derived from the cranioneural crest cells, and a simple layer of undifferentiated ectoderm 6,27 .…”

mentioning

confidence: 99%

“…A cleft palate occurs when the bilateral palatal shelves fail to fuse in the midline interface 30 . This development of the palatal shelves (palatogenesis) is mouse strain specific and may differ up to 1 day 20,24 .…”

mentioning

confidence: 99%

“…The attributes of both strains are well known (www.jax.org). The A/WySnJ strain presents a high spontaneous cleft lip and palate (CL/P) rate of 38 14,19 to 50% 20,24 whilst the NMRI strain has a low spontaneous palatal cleft incidence of 0.7-3.8% 17,19,20,24 . These genetically different mouse strains were chosen for their palatal developmental behaviour and palatal fusion potential in organ culture.…”

mentioning

confidence: 99%

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