The Tips Project

Johannessen, Jan Olav; Larsen, Tor Ketil; Horneland, Marthe; Joa, Inge; Mardal, Sigurd; Kvebæk, Rune; Friis, Svein; Melle, Ingrid; Opjordsmoen, Stein; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas H.

doi:10.1007/978-94-010-0892-1_8

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…As of yet, no such efforts have been directed at the premorbid, asymptomatic phase of schizophrenia. The Early Psychosis Prevention and Intervention Centre in Melbourne, Australia, and the Early Treatment and Identification of Psychosis (TIPS) program in Rogaland County, Norway, have used a multimodal approach (combining public service education, an early detection network, and active engagement of consumers) to reduce the duration of psychosis following first break (McGorry et al 1996; Johannessen et al 2001). Great strides have also been made in the development of criteria for prospectively identifying prodromal schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the associated reduction of illness severity and chronicity, there is currently much interest in early intervention with schizophrenia (Miller et al 2001), either at first break (Wyatt 1991; Loebel et al 1992; McGorry et al 1996; Johannessen et al 2001) or during the prodromal stage (Falloon 1992; McGlashan et al 2001). If future cases of schizophrenia could be accurately identified premorbidly in adolescence, it would facilitate efforts to engage and monitor these individuals prior to prodromal symptoms.…”

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confidence: 99%

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A Multivariate Prediction Model of Schizophrenia

Carter

Schulsinger

Parnas

et al. 2002

Schizophrenia Bulletin

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Univariate prediction models of schizophrenia may be adequate for hypothesis testing but are narrowly focused and limited in predictive efficacy. Therefore, we used a multivariate design to maximize the prediction of schizophrenia from premorbid measures and to evaluate the relative importance of various predictors. Two hundred twelve Danish subjects with at least one parent diagnosed in the schizophrenia spectrum (high risk) and 99 matched subjects with no such parent (low risk) were assessed on 25 premorbid variables in seven domains (genetic risk, birth factors, autonomic responsiveness, cognitive functioning, rearing environment, personality, and school behavior) when the subjects averaged 15 years of age. Twenty-five years later, 33 subjects had received lifetime diagnoses of schizophrenia. Discriminant function analyses were used to discriminate schizophrenia outcomes from no mental illness and nonschizophrenia outcomes on the basis of premorbid measures. Regardless of the comparison group used, schizophrenia was predicted by the interaction of genetic risk with rearing environment, and disruptive school behavior. Within the high-risk group, two-thirds of schizophrenia outcomes were correctly predicted by these premorbid measures; three-quarters of those with no mental illness were also correctly predicted. Prediction was enhanced among those with two schizophrenia spectrum parents, lending support to a multiplicative gene x environment model. Implications for early identification/primary prevention efforts are discussed.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A Multivariate Prediction Model of Schizophrenia

Carter

Schulsinger

Parnas

et al. 2002

Schizophrenia Bulletin

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“…In any case, these models have been critiqued for not including efforts to achieve earlier interventions, within a ‘critical period’ of 2–3 years from psychosis onset, in order to mitigate the impacts of untreated psychosis [ 64 , 65 ]. There have been only a small number of evaluations of interventions to reduce DUP in high-income countries, with limited evidence of sustainable impacts [ 66 ], except for a high quality study testing a multi-component intervention in Norway [ 67 ]. We are not aware of studies from LMIC where impact of interventions on DUP has been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Studying the context of psychoses to improve outcomes in Ethiopia (SCOPE): Protocol paper

Hanlon,

Roberts,

Misganaw

et al. 2024

PLoS ONE

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Background Global evidence on psychosis is dominated by studies conducted in Western, high-income countries. The objectives of the Study of Context Of Psychoses to improve outcomes in Ethiopia (SCOPE) are (1) to generate rigorous evidence of psychosis experience, epidemiology and impacts in Ethiopia that will illuminate aetiological understanding and (2) inform development and testing of interventions for earlier identification and improved first contact care that are scalable, inclusive of difficult-to-reach populations and optimise recovery. Methods The setting is sub-cities of Addis Ababa and rural districts in south-central Ethiopia covering 1.1 million people and including rural, urban and homeless populations. SCOPE comprises (1) formative work to understand care pathways and community resources (resource mapping); examine family context and communication (ethnography); develop valid measures of family communication and personal recovery; and establish platforms for community engagement and involvement of people with lived experience; (2a) a population-based incidence study, (2b) a case-control study and (2c) a cohort study with 12 months follow-up involving 440 people with psychosis (390 rural/Addis Ababa; 50 who are homeless), 390 relatives and 390 controls. We will test hypotheses about incidence rates in rural vs. urban populations and men vs. women; potential aetiological role of khat (a commonly chewed plant with amphetamine-like properties) and traumatic exposures in psychosis; determine profiles of needs at first contact and predictors of outcome; (3) participatory workshops to develop programme theory and inform co-development of interventions, and (4) evaluation of the impact of early identification strategies on engagement with care (interrupted time series study). Findings will inform development of (5) a protocol for (5a) a feasibility cluster randomised controlled trial of interventions for people with recent-onset psychosis in rural settings and (5b) two uncontrolled pilot studies to test acceptability, feasibility of co-developed interventions in urban and homeless populations.

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“…In any case, these models have been critiqued for not including efforts to achieve earlier interventions, within a ‘critical period’ of 2-3 years from psychosis onset, in order to mitigate the impacts of untreated psychosis [63, 64]. There have been only a small number of evaluations of interventions to reduce DUP in high-income countries, with limited evidence of sustainable impacts [65], except for a high quality study testing a multi-component intervention in Norway [66]. We are not aware of studies from LMIC where impact of interventions on DUP has been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Studying the context of psychoses to improve outcomes in Ethiopia (SCOPE): protocol paper

Hanlon,

Roberts,

Misganaw

et al. 2023

Preprint

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BackgroundGlobal evidence on psychosis is dominated by studies conducted in Western, high-income countries. The objectives of the Study of Context Of Psychoses to improve outcomes in Ethiopia (SCOPE) are (1) to generate rigorous evidence of psychosis experience, epidemiology and impacts in Ethiopia that will illuminate aetiological understanding and (2) inform development and testing of interventions for earlier identification and improved first contact care that are scalable, inclusive of difficult-to-reach populations and optimise recovery.MethodsThe setting is sub-cities of Addis Ababa and rural districts in south-central Ethiopia covering 1.1 million people and including rural, urban and homeless populations. SCOPE comprises (i) formative work to understand care pathways and community resources (resource mapping); examine family context and communication (ethnography); develop valid measures of family communication and personal recovery; and establish platforms for community engagement and involvement of people with lived experience; (ii) a population-based incidence study, case-control study and cohort study with 12 months follow-up involving 440 people with psychosis (390 rural/Addis Ababa; 50 who are homeless), 390 relatives and 390 controls. We will test hypotheses about incidence rates in rural vs. urban populations and men vs. women; potential aetiological role of khat (a commonly chewed plant with amphetamine-like properties) and traumatic exposures in psychosis; determine profiles of needs at first contact and predictors of outcome; (iii) participatory workshops to develop programme theory and inform co-development of interventions, (iv) evaluation of the impact of early identification strategies on engagement with care (interrupted time series study); (v) a feasibility cluster randomised controlled trial of interventions for people with recent-onset psychosis in rural settings (10-12 clusters; n=80 participants) with 6 months follow-up to inform a future large-scale trial and investigate implementation processes and outcomes, and (vi) two uncontrolled pilot studies to test acceptability, feasibility of co-developed interventions in urban and homeless populations.

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The Tips Project

Cited by 7 publications

References 31 publications

A Multivariate Prediction Model of Schizophrenia

A Multivariate Prediction Model of Schizophrenia

Studying the context of psychoses to improve outcomes in Ethiopia (SCOPE): Protocol paper

Studying the context of psychoses to improve outcomes in Ethiopia (SCOPE): protocol paper

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