The TMS Motor Map Does Not Change Following a Single Session of Mirror Training Either with Or without Motor Imagery

Ruit, Mark van de; Grey, Michael J.

doi:10.3389/fnhum.2017.00601

Cited by 3 publications

(3 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this short-term increase failed to lead to long-term changes; Three days after rTMS application, the extent of the fMRI responses was identical to the pre-rTMS stimulation ones. It is plausible that the one-time rTMS application was not long enough to induce long-term plasticity, which is also supported by human studies [32]. Another interesting observation was that rTMS alone was more effective than combining 10 Hz rTMS with 3Hz sensory stimulation.…”

Section: Discussionmentioning

confidence: 73%

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

Zhong¹,

Cywiak²,

Metto³

et al. 2021

Brain Stimulation

View full text Add to dashboard Cite

Background:Combining training or sensory stimulation with non-invasive brain stimulation has shown to improve performance in healthy subjects and improve brain function in patients after brain injury. However, the plasticity mechanisms and the optimal parameters to induce long-term and sustainable enhanced performance remain unknown. Objective: This work was designed to identify the protocols of which combining sensory stimulation with repetitive transcranial magnetic stimulation (rTMS) will facilitate the greatest changes in fMRI activation maps in the rat's primary somatosensory cortex (S1). Methods: Several protocols of combining forepaw electrical stimulation with rTMS were tested, including a single stimulation session compared to multiple, daily stimulation sessions, as well as synchronous and asynchronous delivery of both modalities. High-resolution fMRI was used to determine how pairing sensory stimulation with rTMS induced short and long-term plasticity in the rat S1. Results: All groups that received a single session of rTMS showed short-term increases in S1 activity, but these increases did not last three days after the session. The group that received a stimulation protocol of 10 Hz forepaw stimulation that was delivered simultaneously with 10 Hz rTMS for five consecutive days demonstrated the greatest increases in the extent of the evoked fMRI responses compared to groups that received other stimulation protocols. Conclusions: Our results provide direct indication that pairing peripheral stimulation with rTMS induces long-term plasticity, and this phenomenon appears to follow a time-dependent plasticity mechanism. These results will be important to lead the design of new training and rehabilitation paradigms and training towards achieving maximal performance in healthy subjects.

show abstract

Section: Discussionmentioning

confidence: 73%

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

Zhong¹,

Cywiak²,

Metto³

et al. 2021

Brain Stimulation

View full text Add to dashboard Cite

show abstract

“…However, this short-term increase failed to lead to long-term changes; Three days after rTMS application, the extent of the fMRI responses was identical to the pre- rTMS stimulation ones. It is plausible that the one-time rTMS application was not long enough to induce long-term plasticity, which is also supported by human studies (27). Thus, the main implication is that for sustainable and long-term changes in cortical function, multiple rTMS sessions are required.…”

Section: Discussionmentioning

confidence: 64%

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

Zhong

Cywiak

Metto

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundCombining training or sensory stimulation with non-invasive brain stimulation has shown to improve performance in healthy subjects and improve brain function in patients after brain injury. However, the plasticity mechanisms and the optimal parameters to induce long-term and sustainable enhanced performance remain unknown.ObjectiveThis work was designed to identify the protocols of which combining sensory stimulation with repetitive transcranial magnetic stimulation (rTMS) will facilitate the greatest changes in fMRI activation maps in the rat’s primary somatosensory cortex (S1).MethodsSeveral protocols of combining forepaw electrical stimulation with rTMS were tested, including a single stimulation session compared to multiple, daily stimulation sessions, as well as synchronous and asynchronous delivery of both modalities. High-resolution fMRI was used to determine how pairing sensory stimulation with rTMS induced short and long-term plasticity in the rat S1.ResultsAll groups that received a single session of rTMS showed short-term increases in S1 activity, but these increases did not last three days after the session. The group that received a stimulation protocol of 10 Hz forepaw stimulation that was delivered simultaneously with 10 Hz rTMS for five consecutive days demonstrated the greatest increases in the extent of the evoked fMRI responses compared to groups that received other stimulation protocols.ConclusionsOur results provide direct indication that pairing peripheral stimulation with rTMS induces long-term plasticity, and this phenomenon appears to follow a time-dependent plasticity mechanism. These results will be important to lead the design of new training and rehabilitation paradigms and training towards achieving maximal performance in healthy subjects.HighlightsA single rTMS session induced short-term changes but they were not sustainableMulti-session delivery of rTMS paired with sensory stimulation induced long-term plasticityrTMS paired with sensory stimulation induced plasticity via time-dependent mechanismDelivery of sensory stimulation only did not induce long-term plasticity

show abstract

“…Fundamentally, the system produces four measurements from the dataset: the center of gravity (COG), the peak value, the map's surface area, and its volume integral. COG is a classic means of representing motor mapping data, typically used to compare motor maps before and after a stimulus meant to initiate neuroplasticity (Wilson et al, 1993; Thickbroom et al, 1998; Guerra et al, 2015; van de Ruit and Grey, 2017). The peak value of the map is also relatively simple and similar to COG, although it is not used as extensively.…”

Section: Key Innovationsmentioning

confidence: 99%

NeuroMeasure: A Software Package for Quantification of Cortical Motor Maps Using Frameless Stereotaxic Transcranial Magnetic Stimulation

Gerber

McLean

Stephen

et al. 2019

Front. Neuroinform.

View full text Add to dashboard Cite

The recent enhanced sophistication of non-invasive mapping of the human motor cortex using MRI-guided Transcranial Magnetic Stimulation (TMS) techniques, has not been matched by refinement of methods for generating maps from motor evoked potential (MEP) data, or in quantifying map features. This is despite continued interest in understanding cortical reorganization for natural adaptive processes such as skill learning, or in the case of motor recovery, such as after lesion affecting the corticospinal system. With the observation that TMS-MEP map calculation and quantification methods vary, and that no readily available commercial or free software exists, we sought to establish and make freely available a comprehensive software package that advances existing methods, and could be helpful to scientists and clinician-researchers. Therefore, we developed NeuroMeasure , an open source interactive software application for the analysis of TMS motor cortex mapping data collected from Nexstim® and BrainSight®, two commonly used neuronavigation platforms. NeuroMeasure features four key innovations designed to improve motor mapping analysis: de-dimensionalization of the mapping data, fitting a predictive model, reporting measurements to characterize the motor map, and comparing those measurements between datasets. This software provides a powerful and easy to use workflow for characterizing and comparing motor maps generated with neuronavigated TMS. The software can be downloaded on our github page: https://github.com/EdwardsLabNeuroSci/NeuroMeasure Aim This paper aims to describe a software platform for quantifying and comparing maps of the human primary motor cortex, using neuronavigated transcranial magnetic stimulation, for the purpose of studying brain plasticity in health and disease.

show abstract

The TMS Motor Map Does Not Change Following a Single Session of Mirror Training Either with Or without Motor Imagery

Cited by 3 publications

References 74 publications

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

NeuroMeasure: A Software Package for Quantification of Cortical Motor Maps Using Frameless Stereotaxic Transcranial Magnetic Stimulation

Contact Info

Product

Resources

About