The TNF-α rs361525 and IFN-γ rs2430561 polymorphisms are associated with liver cirrhosis risk: a comprehensive meta-analysis

Abstract

BackgroundInflammation serves as an essential driver of liver cirrhosis (LC) incidence. Accordingly, a meta-analysis was carried out to explore the association between specific polymorphisms in the interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) genes and the incidence of LC based on comparisons of genotype and allele frequencies.ObjectivesTo study the relationship between TNF-α rs361525 and IFN-γ rs2430561 polymorphisms and the risk of LC.MethodsA database search was performed for all studies published as of September 10, 2022. The strength of risk relationships was assessed based on odds ratios (ORs) with 95% confidence intervals (CIs).ResultsPooled analyses were conducted for one common TNF-α polymorphism (rs361525) as well as one common IFN-γ polymorphism (rs2430561). Both of these SNPs were identified as LC-related risk factors. Specifically, rs361525 was related to LC incidence in both alcoholic liver cirrhosis (OR: 1.86, 95%CI: 1.03-3.34) and hepatitis B virus (HBV)-related cirrhosis cases (OR: 1.44, 95%CI: 1.00-2.06) when using an allelic contrast model. Moreover, rs2430561 was significantly related to LC in an Asian population (OR: 1.45, 95%CI: 1.13-1.86) and in the context of HBV-related cirrhosis (OR: 1.48, 95%CI: 1.13-1.93) when using an allelic contrast model.ConclusionThese findings indicate that rs361525 and rs2430561 represent LC-related risk factors, although additional large-scale clinical and case-control studies will be vital to confirm these results.

Analysis of Mutational Status of IGHV, and Cytokine Polymorphisms as Prognostic Factors in Chronic Lymphocytic Leukemia: The Romanian Experience

“…Variations located in the promoter region of the TNF-α gene (such as rs1800750 at position −376G/A and rs361525 at position −238G/A) [36,37] are believed to impact the expression of TNF-α and are recognized as functional single-nucleotide polymorphisms (SNPs) [35]. The rs361525 polymorphism has been linked to different hemato-oncologic conditions such as chronic myeloid leukemia (CML) [13]; other types of cancers including breast cancer, lymphoma [37], gastric cancer [38], and lung cancer [39]; and various other medical conditions such as graft versus host disease, ear infections in children, nasal polyps, diabetes, the decline of verbal memory, and sudden infant death syndrome [37], as well as liver cirrhosis [40], psoriasis [41], and systemic sclerosis [42]. The rs1800750 polymorphism has also been investigated in different conditions, like cancer, diabetes, migraine, or multiple sclerosis [36], but to the best of our knowledge, not in CLL.…”