The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

Hikisz, Paweł; Jacenik, Damian

doi:10.3390/cells12060879

Cited by 38 publications

(22 citation statements)

References 180 publications

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“…In conclusion, we report for the first time that acrolein induces an increase in [Zn 2 ⁺]ᵢ levels by stimulating the mitochondrial oxidative stress production pathway. For some respiratory diseases, such as COPD or cancer, the latest study has shown that ROS production induced by acrolein is closely related to the occurrence and development of diseases (Hikisz and Jacenik, 2023). Another study showed that intracellular Zn 2 ⁺ can be increased in a short period of time by ROS, which may be an antioxidant feedback mechanism (Truong-Tran et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Acrolein increases the concentration of intracellular Zn²⁺ by producing mitochondrial reactive oxygen species in A549 cells

Liu,

Sun,

Cao

et al. 2023

Toxicol Ind Health

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Smoking or occupational exposure leads to low concentrations of acrolein on the surface of the airways. Acrolein is involved in the pathophysiological processes of various respiratory diseases. Reports showed that acrolein induced an increase in mitochondrial reactive oxygen species (mROS). Furthermore, exogenous H₂O₂ was found to increase intracellular Zn2⁺ concentration ([Zn2⁺]ᵢ). However, the specific impact of acrolein on changes in intracellular Zn2⁺ levels has not been fully investigated. Therefore, this study aimed to investigate the effects of acrolein on mROS and [Zn2⁺]ᵢ in A549 cells. We used Mito Tracker Red CM-H2Xros (MitoROS) and Fluozin-3 fluorescent probes to observe changes in mROS and intracellular Zn2⁺. The results revealed that acrolein increased [Zn2⁺]ᵢ in a time- and dose-dependent manner. Additionally, the production of mROS was observed in response to acrolein treatment. Subsequent experiments showed that the intracellular Zn2⁺ chelator TPEN could inhibit the acrolein-induced elevation of [Zn2⁺]ᵢ but did not affect the acrolein-induced mROS production. Conversely, the acrolein-induced elevation of mROS and [Zn2⁺]ᵢ were significantly decreased by the inhibitors of ROS formation (NaHSO₃, NAC). Furthermore, external oxygen free radicals increased both [Zn2⁺]ᵢ levels and mROS production. These results demonstrated that acrolein-induced elevation of [Zn2⁺]ᵢ in A549 cells was mediated by mROS generation, rather than through a pathway where [Zn2⁺]ᵢ elevation leads to mROS production.

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Section: Discussionmentioning

confidence: 99%

Acrolein increases the concentration of intracellular Zn²⁺ by producing mitochondrial reactive oxygen species in A549 cells

Liu,

Sun,

Cao

et al. 2023

Toxicol Ind Health

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“…From the volatile organic compounds (VOCs) listed among the chemical components of the emissions of 3D printers, acrolein is a potential concern from the perspective of lung carcinogenicity (Hikisz & Jacenik, 2023). However, IARC found the evidence regarding cancer in humans caused by acrolein exposure inadequate (IARC, 2021).…”

Section: Discussionmentioning

confidence: 99%

Using particle dimensionality‐based modeling to estimate lung carcinogenicity of 3D printer emissions

Korchevskiy,

Hill,

Hull

et al. 2023

J of Applied Toxicology

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The use of 3D printing technologies by industry and consumers is expanding. However, the approaches to assess the risk of lung carcinogenesis from the emissions of 3D printers have not yet been developed.The objective of the study was to demonstrate a methodology for modeling lung cancer risk related to specific exposure levels as derived from an experimental study of 3D printer emissions for various types of filaments (ABS, PLA, and PETG).The emissions of 15 filaments were assessed at varying extrusion temperatures for a total of 23 conditions in a Class 1,000 cleanroom following procedures described by ANSI/CAN/UL 2904. Three approaches were utilized for cancer risk estimation: (a) calculation based on PM2.5 and PM10 concentrations, (b) a proximity assessment based on the pulmonary deposition fraction, and (c) modeling based on the mass‐weighted aerodynamic diameter of particles.The combined distribution of emitted particles had the mass median aerodynamic diameter (MMAD) of 0.35 μm, GSD 2.25. The average concentration of PM2.5 was 25.21 μg/m3. The spline‐based function of aerodynamic diameter allowed us to reconstruct the carcinogenic potential of seven types of fine and ultrafine particles (crystalline silica, fine TiO2, ultrafine TiO2, ambient PM2.5 and PM10, diesel particulates, and carbon nanotubes) with a correlation of 0.999, P < 0.00001. The central tendency estimation of lung cancer risk for 3D printer emissions was found at the level of 14.74 cases per 10,000 workers in a typical exposure scenario (average cumulative exposure of 0.3 mg/m3 – years), with the lowest risks for PLA filaments, and the highest for PETG type.

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“…Based on the IARC's (2017) compilation of carcinogens, ACR was classified as “not classifiable as to its carcinogenicity to humans” (Group 3). However, extensive research has established a significant association between ACR and prevalent chronic illnesses, such as Alzheimer's disease (AD) (Lovell et al., 2001), Parkinson's disease (Jomova et al., 2010), and respiratory cancers (Hikisz & Jacenik, 2023).…”

Section: Influence Of Anthocyanins On Contaminants From Food Processingmentioning

confidence: 99%

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

Jiang,

Li,

Zhang

et al. 2023

Comp Rev Food Sci Food Safe

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Foodborne contaminants refer to substances that are present in food and threaten food safety. Due to the progress in detection technology and the rising concerns regarding public health, there has been a surge in research focusing on the dangers posed by foodborne contaminants. These studies aim to explore and implement strategies that are both safe and efficient in mitigating the associated risks. Anthocyanins, a class of flavonoids, are abundantly present in various plant species, such as blueberries, grapes, purple sweet potatoes, cherries, mulberries, and others. Numerous epidemiological and nutritional intervention studies have provided evidence indicating that the consumption of anthocyanins through dietary intake offers a range of protective effects against the detrimental impact of foodborne contaminants. The present study aims to differentiate between two distinct subclasses of foodborne contaminants: those that are generated during the processing of food and those that originate from the surrounding environment. Furthermore, the impact of anthocyanins on foodborne contaminants was also summarized based on a review of articles published within the last 10 years. However, further investigation is warranted regarding the mechanism by which anthocyanins target foodborne contaminants, as well as the potential impact of individual variations in response. Additionally, it is important to note that there is currently a dearth of clinical research examining the efficacy of anthocyanins as an intervention for mitigating the effects of foodborne pollutants. Thus, by exploring the detoxification effect and mechanism of anthocyanins on foodborne pollutants, this review thereby provides evidence, supporting the utilization of anthocyanin‐rich diets as a means to mitigate the detrimental effects of foodborne contaminants.

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The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

Cited by 38 publications

References 180 publications

Acrolein increases the concentration of intracellular Zn²⁺ by producing mitochondrial reactive oxygen species in A549 cells

Acrolein increases the concentration of intracellular Zn²⁺ by producing mitochondrial reactive oxygen species in A549 cells

Using particle dimensionality‐based modeling to estimate lung carcinogenicity of 3D printer emissions

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

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The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

Cited by 38 publications

References 180 publications

Acrolein increases the concentration of intracellular Zn2⁺ by producing mitochondrial reactive oxygen species in A549 cells

Acrolein increases the concentration of intracellular Zn2⁺ by producing mitochondrial reactive oxygen species in A549 cells

Using particle dimensionality‐based modeling to estimate lung carcinogenicity of 3D printer emissions

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

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Product

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Acrolein increases the concentration of intracellular Zn²⁺ by producing mitochondrial reactive oxygen species in A549 cells

Acrolein increases the concentration of intracellular Zn²⁺ by producing mitochondrial reactive oxygen species in A549 cells