The Tongue as an Alternative Donor Site for Graft Urethroplasty: A Pilot Study

Simonato, Alchiede; Gregori, Andrea; Lissiani, A.; Galli, Stefano; Ottaviani, F.; Rossi, Roberta; Zappone, Anna; Carmignani, G.

doi:10.1016/s0022-5347(05)00166-7

Cited by 107 publications

(135 citation statements)

References 18 publications

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“…Simonato et al [33] First report on the use of tongue mucosa Figure 1: Histology of buccal mucosa [60] Figure 2: Microvasculature of buccal mucosa [60] …”

Section: Historical Perspectivementioning

confidence: 99%

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Oral mucosa grafts for urethral reconstruction

Mungadi

Ugboko

2009

Ann Afr Med

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Background: Urethral reconstruction has continued to present formidable and enormous challenges for urologic, paediatric and plastic surgeons as diverse opinions have been expressed on the quality and type of ideal substitution material. This literature review is aimed at drawing attention of surgeons to the versatile nature of oral mucosal grafts. Methods: A review of the utilization of oral mucosa in urethral reconstruction was made. Structured Medline search was performed looking at all aspects of utilization of oral mucosa including mucosal harvest, donor site morbidity and outcome. Results: The unique demands of the urethra set a high standard for autogenous graft substitutes; hence literature reports reveal that split and full thickness skin grafts from the scrotum, penis, extragenital sites (ureter, saphenous vein, appendix, colon, medial upper arm, neck, lateral chest, abdomen, bladder mucosa) and more recently oral mucosa have been used. Unlike other tissues, oral mucosa grafts are fl exible, easy to harvest and trim and have an excellent microvasculature favorable for graft-taking. Furthermore, the natural moist location of the oral mucosa in the oral environment favours its easy adaptability in the urethral passage thus giving good long-term results. However, there are reports of complications at the donor site with the commonest being anaesthesia or paraesthesia of the cheek or lips. Regional variations of the oral mucosa, length of the graft required, the decision to close or leave donor site open and harvesting technique are some of the factors suggested to account for differences in donor site morbidity. Conclusion: Oral mucosal graft is a versatile urethral substitute with excellent outcome. It is becoming the gold standard for urethral substitution.

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“…Simonato et al [33] First report on the use of tongue mucosa Figure 1: Histology of buccal mucosa [60] Figure 2: Microvasculature of buccal mucosa [60] …”

Section: Historical Perspectivementioning

confidence: 99%

“…[33] The lateral surface of the tongue offers a short mucosa, of about 7-8 cm long, and both lateral surfaces are available as donor sites if the need arises. [33] …”

Section: Tongue Mucosamentioning

confidence: 99%

Oral mucosa grafts for urethral reconstruction

Mungadi

Ugboko

2009

Ann Afr Med

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“…(46) Among the good results of the oral mucosa urethroplasty, the lingual mucosa is no exception. In their pioneering report, Simonato et al (20) reported seven successful cases out of the 8 cases included in his study achieving a success rate of 87.5%. (20) In a following report, they reported a series of 29 patients with anterior urethral strictures who underwent urethral reconstruction using LMG.…”

Section: Results Of Oral Mucosa Urethroplastymentioning

confidence: 95%

“…(12)(13)(14)(15)(16)(17)(18)(19) Nowadays, buccal mucosa has become the mainstay of these tissue transfer techniques. (13) In February 2006, Simonato et al (20) described the results of the first pilot study on the use of the tongue as an alternative donor site for graft urethroplasty with good functional and aesthetic results. (20) One year later in a dog model, Song et al (21) investigated the feasibility of the LMG urethroplasty.…”

mentioning

confidence: 99%

“…(13) In February 2006, Simonato et al (20) described the results of the first pilot study on the use of the tongue as an alternative donor site for graft urethroplasty with good functional and aesthetic results. (20) One year later in a dog model, Song et al (21) investigated the feasibility of the LMG urethroplasty. Macroscopic examination of the graft showed no ulceration, calcification, strictures, diverticulae or fistula formation.…”

mentioning

confidence: 99%

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Oral Mucosa Graft: An Ideal Substitute for Urethroplasty

Ragab¹,

Haroun²

2011

Current Concepts of Urethroplasty

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An Integrated Whole‐Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction

Fang,

Wang,

Zhang

et al. 2024

Advanced Science

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The harsh microenvironment of the urethral injury often carries high risks of early undesirable healing as well as late scar tissue formation. Indeed, the infection and inflammatory response in the early stages as well as blood vessel formation and tissue regeneration in the later stages fundamentally impact the outcomes of urethral wound healing. Innovatively, an integrated whole‐process repair hydrogel (APF/C/L@dECM) is designed. After rigorous testing, it is found that hydrogels formed by hydrophobic association and double cross‐linking of amide bonds can procedurally regulate wound healing in all phases to match the repair process. In rabbit models of urethral wound, APF/C/L@dECM hydrogel can achieve scarless reconstruction with significantly better results than other hydrogels. Noteworthily, multi‐stage mechanistic explorations reveal the expression profiles of inflammation, vascularization, and extracellular matrix secretion‐related genes in wound tissue at different times. In summary, this study develops an overall treatment for urethral injury through a whole‐process repair system that promotes healthy healing of urethral wounds and prevents the formation of scar tissue.

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The Tongue as an Alternative Donor Site for Graft Urethroplasty: A Pilot Study

Abstract: Harvesting the LMG is feasible and easy to perform. Compared with the buccal mucosal graft the LMG seems to be associated with less postoperative pain and a minor risk of donor site complications. These preliminary functional and esthetic data are satisfactory.

Cited by 107 publications

References 18 publications

Oral mucosa grafts for urethral reconstruction

Oral mucosa grafts for urethral reconstruction

Oral Mucosa Graft: An Ideal Substitute for Urethroplasty

An Integrated Whole‐Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction

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