The Top of the Biomimetic Triangle

Sommer, Andrei P.; Zhu, Dan; Wiora, Matthias; Fecht, Hans-Joerg

doi:10.1016/s1672-6529(08)60011-6

Cited by 15 publications

(6 citation statements)

References 16 publications

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“…1 Figure 4 shows rat neuronal cells (PC-12 cells) directly after seeding on two substrates of identical topography: (a) nanocrystalline diamond and (b) hydrogenated nanocrystalline diamond. The layer of ordered water molecules should be more stable here andbecause of unilateral restriction in mobility by the surface-also more dense than on the diamond.…”

Section: Interfacial Water Layers On Diamond: Biological Importancementioning

confidence: 99%

Biomimetics: Learning from diamonds

et al. 2008

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There is increasing observational evidence for an implication of the order of interfacial water layers in biology, for instance in processes of cellular recognition and during first contact events, where cells decide to survive or enter apoptosis. Experimental methods that allow access to the order of interfacial water layers are thus crucial in biomedical engineering. In this study, we show that interfacial water structures can be nondestructively analyzed on the nanocrystalline diamond. Results open the gate to a new chapter in the design of biomaterials inspired by biomimetic principles.

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Section: Interfacial Water Layers On Diamond: Biological Importancementioning

confidence: 99%

Biomimetics: Learning from diamonds

et al. 2008

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“…Interestingly, at low temperature, hydrophobic graphite was found to form stable and highly ordered networks of interfacial water. 12 Recently, we provided evidence for the importance of ordered interfacial water layers in the design of biomaterials 13,14 and their implication in maintaining the elasticity of elastin fibers in juvenile tissue. 15 Probably, similar water layers are *To whom correspondence should be addressed.…”

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confidence: 99%

Interfacial Water an Exceptional Biolubricant

Sommer

Zhu

Mester³

et al. 2009

Crystal Growth & Design

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Interfacial water layers attract more and more attention in both material sciences and life sciences because of two characteristics that depend on the polarity of the surfaces involved: crystalline order and surface stability. Their interplay allows us to understand friction at the nanoscale under realistic conditions, including but not limited to the extremely low friction between hydrogenated diamond species, the enhanced flow in carbon nanotubes, or the functionality of elastin fibers. The prospect that the low friction coefficients both in artificial systems and nature are due to the action of interfacial water layers is challenging and deserves study. Here we probed the bonding stability of water molecules on hydrogenated and non-hydrogenated diamond surfaces and found that the interfacial water layer masking hydrogenated diamond presents an exceptional stability, thereby explaining its direct involvement in lubrication.

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“…In relation with this, Sommer et al . addressed key determinants of biocompatibility called as biomimetic triangle 45 . The report suggest that the parameters of biomimetic triangle should be considered for generation of optimal osteogenic plates.…”

Section: Discussionmentioning

confidence: 99%

Nanotopological plate stimulates osteogenic differentiation through TAZ activation

Hwang

Lee

Byun

et al. 2017

Sci Rep

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The topographical environment, which mimics the stem cell niche, provides mechanical cues to regulate the differentiation of mesenchymal stem cells (MSC). Diverse topographical variations have been engineered to investigate cellular responses; however, the types of mechanical parameters that affect cells, and their underlying mechanisms remain largely unknown. In this study, we screened nanotopological pillars with size gradient to activate transcriptional coactivator with PDZ binding motif (TAZ), which stimulates osteogenesis of MSC. We observed that a nanotopological plate, 70 nm in diameter, significantly induces osteogenic differentiation with the activation of TAZ. TAZ activation via the nanotopological plate was mediated by actin polymerization and Rho signaling, as evidenced by the cytosolic localization of TAZ under F-actin or Rho kinase inhibitor. The FAK and MAPK pathways also play a role in TAZ activation by the nanotopological plate because the inhibitor of ERK and JNK blocked nanopattern plate induced osteogenic differentiation. Taken together, these results indicate that nanotopology regulates cell differentiation through TAZ activation.

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The Top of the Biomimetic Triangle

Cited by 15 publications

References 16 publications

Biomimetics: Learning from diamonds

Biomimetics: Learning from diamonds

Interfacial Water an Exceptional Biolubricant

Nanotopological plate stimulates osteogenic differentiation through TAZ activation

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