The Topical Effect of Grape Seed Extract 2% Cream on Surgery Wound Healing

Abstract

Background:Reducing the wound healing time is crucial in wound as it lowers the chance of infection and decreases complications and cost. Grape seed extract has the ability to release endothelial growth factor and its topical application results in contraction and closure of the skin wound. Furthermore, it possesses antioxidant and antibacterial properties. In several studies it has been proved effective in animals. Therefore, due to low side effects and recognition of herbal medicine, we decided to evaluate the effect of grape seed extract 2% herbal cream on human skin lesions.Materials:This study is a double blind clinical trial conducted on two groups of treatment and placebo. Surgery was performed on skin lesions such as skin tags and moles which were found on the neck, trunk and limbs (except for face). After enrollment and obtaining informed consent from participants, they were randomized into two groups of treatment and placebo. Excision of the lesions was done by surgical scissors. The lesions got restored by secondary intention method. After the first day of treatment, the patients were visited on the 3rd, 7th, 10th, 14th, and 21st day. Grape seed extract cream 2% was produced and coded by the Faculty of Pharmacy, Ahvaz University of Medical Sciences. In order to compare the two groups, T-test was used. For time assessing, analysis of variance with repeated measures was employed.Results:The results showed complete repair of wounds averagely on day 8 for the treatment group and on day 14 for the placebo group, which was clearly significant in terms of statistical difference (p=0.00).Conclusion:Proanthocyanidins in grape seed extract trigger the release of vascular endothelial growth factor and its topical application causes wound contraction and closure. Curing skin lesions with grape seed extract caused proliferation areas with protected boundaries in epithelium, increased cell density and increased deposition of connective tissue at the wound site which in general improves cellular structure in wound. In addition, its anti-inflammatory and anti-microbial properties are effective in wound healing.

The Effects of Grape Seed Extract Ointment on Approximation of Cesarean Section Wound

“…Their findings showed that in the intervention and placebo groups, complete wound healing occurred, respectively, on the eighth and the fourteenth post-surgery days, respectively. Their statistical analyses showed a significant difference between the groups regarding the time of achieving recovery (P < 0.001) (19). In line with our findings, their findings confirmed the positive effects of grape seed extract on wound healing.…”

Nano formulated proanthocyanidins as an effective wound healing component

“…PCs also helps in promoting the formation of collagen and elastin and preservation of skin moisture. Furthermore, PCs induces vascular endothelial growth factor, reduces edema and encourages blood flow thereby accelerates wound healing [28][29][30][31][32][33]. Khanna et al reported the outcome of grape seed extract (GSE) on in-vivo wound healing among nine male BalbC mice.…”

Wound Healing Effects of Rose Placenta in a Mouse Model of Full-Thickness Wounds

“…Studies have suggested that the use of herbal medicines may accelerate the wound healing process by promoting growth factor release. For example, grape seed extract triggers the release of VEGF [ 16 ]. R. damascena is also involved in the enhancement of neurite outgrowth [ 17 ].…”