The topographical organization of motor processing: An ALE meta-analysis on six action domains and the relevance of Broca’s region

Papitto, Giorgio; Friederici, Angela D.; Zaccarella, Emiliano

doi:10.31234/osf.io/wkcun

Cited by 9 publications

(10 citation statements)

References 194 publications

(306 reference statements)

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“…This suggests that these regions do not process stimulus properties or aspects of manual, facial, and bodily gestures but are specifically recruited by deaf signers for attributing linguistic information to the observed gestures. Convergence in right IFG, parts of right STG, bilateral insula cortex, as well as bilateral occipital and posterior middle and inferior temporal gyrus was also observed during observation of SLA in hearing nonsigners, indicating that these regions subserve perceptual as well as other nonlinguistic processes involved in action observation (Papitto et al, 2020). Interestingly, such a functional specialization of the left hemisphere and especially the left IFG for processing abstract linguistic information has also been reported in studies of the comprehension of conventionalized symbolic gesture by hearing nonsigners (Özyürek, 2014; Xu, Gannon, Emmorey, Smith, & Braun, 2009), thereby hinting at the supramodal nature of the brain's core network for language processing independent of stimulus properties.…”

Section: Discussionmentioning

confidence: 99%

“…In this analysis, we tested the SLA observation dataset derived from an independent meta‐analysis (Papitto, Friederici, & Zaccarella, 2020), as described in Appendix A. Here, we sought to determine brain regions recruited in (hearing) subjects during processing of visual stimuli showing humans performing manual and facial actions devoid of linguistic content.…”

Section: Methodsmentioning

confidence: 99%

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Functional neuroanatomy of language without speech: An ALE meta‐analysis of sign language

Trettenbrein

Papitto

Friederici

et al. 2020

Human Brain Mapping

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Sign language (SL) conveys linguistic information using gestures instead of sounds. Here, we apply a meta‐analytic estimation approach to neuroimaging studies (N = 23; subjects = 316) and ask whether SL comprehension in deaf signers relies on the same primarily left‐hemispheric cortical network implicated in spoken and written language (SWL) comprehension in hearing speakers. We show that: (a) SL recruits bilateral fronto‐temporo‐occipital regions with strong left‐lateralization in the posterior inferior frontal gyrus known as Broca's area, mirroring functional asymmetries observed for SWL. (b) Within this SL network, Broca's area constitutes a hub which attributes abstract linguistic information to gestures. (c) SL‐specific voxels in Broca's area are also crucially involved in SWL, as confirmed by meta‐analytic connectivity modeling using an independent large‐scale neuroimaging database. This strongly suggests that the human brain evolved a lateralized language network with a supramodal hub in Broca's area which computes linguistic information independent of speech.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Functional neuroanatomy of language without speech: An ALE meta‐analysis of sign language

Trettenbrein

Papitto

Friederici

et al. 2020

Human Brain Mapping

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“…The MNI coordinates for BA44 were defined according to the results of Zaccarella and Friederici (2015), who found increased activation for phrases compared to word lists in this region. This target is located in the most anterior and ventral part of BA44, which is functionally specialized in syntactic computations (Papitto et al, 2020;Zaccarella et al, 2021).…”

Section: Transcranial Magnetic Stimulation (Tms)mentioning

confidence: 99%

Towards a causal role of Broca’s area in language: A TMS-EEG study on syntactic prediction

Maran

Numssen

Hartwigsen

et al. 2021

Preprint

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Categorical predictions have been proposed as the key mechanism supporting the fast pace of syntactic composition in human language. Accordingly, grammar-based expectations facilitate the analysis of incoming syntactic information - e.g., hearing the determiner 'the' enhances the prediction of a noun - which is then checked against a single or few other word categories. Previous functional neuroimaging studies point towards Broca's area in the left inferior frontal gyrus (IFG) as one fundamental cortical region involved in categorical prediction during on-line language processing. Causal evidence for this hypothesis is however still missing. In this study, we combined Electroencephalography (EEG) and Transcranial Magnetic Stimulation (TMS) to test whether Broca's area is functionally relevant in predictive mechanisms for language. Specifically, we transiently perturbed Broca's area during the categorical prediction phase in two-word constructions, while simultaneously measuring the Event-Related Potential (ERP) correlates of syntactic composition. We reasoned that if Broca's area is involved in predictive mechanisms for syntax, disruptive TMS during the processing of the first word (determiner/pronoun) would mitigate the difference in ERP responses for predicted and unpredicted categories when composing basic phrases and sentences. Contrary to our hypothesis, perturbation of Broca's area at the predictive stage did not affect the ERP correlates of basic composition. The correlation strength between the electrical field induced by TMS and the magnitude of the EEG response on the scalp further confirmed this pattern. We discuss the present results in light of an alternative account of the role of Broca's area in syntactic composition, namely the bottom-up integration of words into constituents.

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“…This algorithm, using input foci (e.g., brain coordinates) from multiple experiments, allows to identify significant convergence among reported coordinates in experiments that is higher than expected from a random distribution of foci (for further details on the ALE method please refer to the original publications of Eickhoff et al, 2012;Eickhoff et al, 2009;and Turkeltaub et al, 2012;Tahmasian et al, 2019). For each ALE calculation, significance was tested using 1000 permutations with a cluster forming threshold at voxel-level p < 0.001 (Eickhoff et al, 2016), and to provide an appropriate compromise between sensitivity and specificity, significance was corrected with a cluster-level family-wise error threshold of p < 0.05 (cFWE; Eickhoff et al, 2016), as in previous meta-analytic studies (Papitto et al, 2020;Teghil et al, 2019).…”

Section: Activation Likelihood Estimation Meta-analysis and Systematimentioning

confidence: 99%

The Neural Bases of Drawing. A Meta-analysis and a Systematic Literature Review of Neurofunctional Studies in Healthy Individuals

Santangelo

Trojano

2021

Neuropsychol Rev

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Drawing is a multi-component process requiring a wide range of cognitive abilities. Several studies on patients with focal brain lesions and functional neuroimaging studies on healthy individuals demonstrated that drawing is associated with a wide brain network. However, the neural structures specifically related to drawing remain to be better comprehended. We conducted a systematic review complemented by a meta-analytic approach to identify the core neural underpinnings related to drawing in healthy individuals. In analysing the selected studies, we took into account the type of the control task employed (i.e. motor or non-motor) and the type of drawn stimulus (i.e. geometric, figurative, or nonsense). The results showed that a fronto-parietal network, particularly on the left side of the brain, was involved in drawing when compared with other motor activities. Drawing figurative images additionally activated the inferior frontal gyrus and the inferior temporal cortex, brain areas involved in selection of semantic features of objects and in visual semantic processing. Moreover, copying more than drawing from memory was associated with the activation of extrastriate cortex (BA 18, 19). The activation likelihood estimation coordinate-based meta-analysis revealed a core neural network specifically associated with drawing which included the premotor area (BA 6) and the inferior parietal lobe (BA 40) bilaterally, and the left precuneus (BA 7).These results showed that a fronto-parietal network is specifically involved in drawing and suggested that a crucial role is played by the (left) inferior parietal lobe, consistent with classical literature on constructional apraxia.

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The topographical organization of motor processing: An ALE meta-analysis on six action domains and the relevance of Broca’s region

Cited by 9 publications

References 194 publications

Functional neuroanatomy of language without speech: An ALE meta‐analysis of sign language

Functional neuroanatomy of language without speech: An ALE meta‐analysis of sign language

Towards a causal role of Broca’s area in language: A TMS-EEG study on syntactic prediction

The Neural Bases of Drawing. A Meta-analysis and a Systematic Literature Review of Neurofunctional Studies in Healthy Individuals

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