The topological structure of hypersurfaces of conformational energy levels and physical mechanisms of the internal mobility of proteins

Abstract

The interrelationshlp between the general characteristics of structure of biopolymer conformatlonal energy hypersurface and possible mechanlsms of conformational movements and elementary acts of functional processes Is considered. The fundamental principle underlying regulatlon and control within blologlcal systems at the macromolecular level are dlscussed. A new approach to modeling the dynamics of functlonal processes Is proposed.

Molecular structure and the dynamics of the functioning of conformationally mobile systems

“…Clearly, the dynamics of self organization is closely connected with the structure of the multidimensional energy surface. Some aspects of this problem are related to Morse the ory [35] and presented in [36][37][38][39][40].…”

“…This is a perfect illustration of an electron confor mational transition. In mathematical terms, the sys tem is described by two coupled Fokker-Planck type equations with additional terms describing chemical reactions [36][37][38][39][40]42].…”