The Tortuous Journey of a Biochemist to Immunoland and What He Found There

Strominger, Jack L.

doi:10.1146/annurev.immunol.24.021605.090703

Cited by 10 publications

(3 citation statements)

References 111 publications

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“…[24–26] We have also shown in in vitro cultures that the induction of CD8+ CTL responses decline in mixed culture with total PBL whereas CTL responses in culture with purified CD8+ cells remain significantly longer in cultures. [25] Table 1 summarizes the results of in vitro cocultures to induce tumor antigen-specific CTL response using total PBL and purified CD8+ cells.…”

Section: Presence Of Fludarabine In Low Dose In Culture-maintained Fumentioning

confidence: 99%

Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy

Chakraborty

2009

Indian J Hum Genet

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Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important.

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Section: Presence Of Fludarabine In Low Dose In Culture-maintained Fumentioning

confidence: 99%

Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy

Chakraborty

2009

Indian J Hum Genet

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“…Jack Strominger, who had moved from St. Louis to the University of Wisconsin at Madison in 1964, was 4 years later being recruited to Harvard. As Strominger recalled, some 40 years on, in the Annual Review of Immunology , at that time he ‘had thought for about a year that the penicillin problem was almost solved and that I should look for new pastures’ . These he found at Harvard by developing a collaborative project with Mann and Sanderson to further the biochemical and structural analysis of HLA antigens.…”

Section: Solubilization and Purification Of Transplantation Antigensmentioning

confidence: 99%

Molecular definition of the transplantation antigens

Parham

2018

The FEBS Journal

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In the first half of the 20th century, the major histocompatibility complex (MHC) of the laboratory mouse, the H-2 complex, was defined by a combination of serology and genetics. In the second half of the 20th century, its human counterpart, the human leukocyte antigen (HLA) complex was similarly defined and shown to mediate rejection of allogeneic kidney grafts. The clinical relevance of the transplantation antigens created the field of transplant immunology, which aimed to reduce graft rejection by HLA matching of transplant donors and recipients, and to use immunosuppressive drugs to prevent and treat rejection. Because tissue transplantation is not a natural phenomenon, the relevance of the MHC for immunology and immune defense against microbial pathogens was frequently questioned. In the 1970s, the general observation that cytotoxic T-cell responses to viral infection required recognition of both a viral antigen and a transplantation antigen argued for the immunological importance of the MHC. Proving this point was not achieved until close to the end of the 20th century. This required detailed biochemical and structural analysis of the transplantation antigens, the viral antigens, and the T-cell receptors that recognized them. This century of research culminated in 1996 with the three-dimensional crystallographic structure of the complex of these three components. In this complex is MAC, the very first HLA antigen to be detected and now more formally known as HLA-A*02:01.

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“…If the HLA molecules contain peptides derived from a pathogen and their level of expression is above normal, then they will be most likely be recognized by the T lymphocytes as foreign, and some form of immune response will ensue. Therefore, the HLA antigens are foremost a system for surveillance and recognition of the intracellular compartment of the human body [5].…”

Section: A Historical Perspective Helpsmentioning

confidence: 99%

Getting the best out of human leucocyte antigen typing

Faner

Palou

Juan

et al. 2007

ISBT Science Series

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Getting value out of human leucocyte antigen (HLA) laboratories requires not only good technology and software but also an understanding of the role of HLA in the immune response and in immunopathology. In this paper, we give some historical background that explains why HLA remains a difficult subject for most laboratory and clinical scientists and we comment on what is known of their function as antigenpresenting molecules. We review then the state of knowledge on the genetics of HLA, which still contains many unresolved questions, not all that surprising since, despite the myriad of association studies, only three extended haplotypes have been fully sequenced to date. The HUGO and HapMap projects have revealed the daunting complexity of this genomic region that not only contains a extremely high density of genes, but it is also the most actively transcribed region of the human genome, probably because it contains many histone-and tRNA-coding genes. Finally, the main typing techniques and what the future may bring are briefly discussed.

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The Tortuous Journey of a Biochemist to Immunoland and What He Found There

Cited by 10 publications

References 111 publications

Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy

Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy

Molecular definition of the transplantation antigens

Getting the best out of human leucocyte antigen typing

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