The Total Incidence of Loco-Regional Recurrence in a Randomized Trial of Breast Cancer Tnm Stage Ii the South Sweden Breast Cancer Trial

Does stage at diagnosis explain the difference in survival after breast cancer in Denmark and Sweden?

“…There were clinical trials for patients up to the age of 70/75 years, led by the South Sweden Breast Cancer Group and the Danish Breast Cancer Cooperative Group (7,8). Trials differed with regard to surgical procedures and radiotherapy schedules as well as in adjuvant anti-oestrogenic and chemotherapy regimens (Table 1).…”

Breast Cancer

“…In patients randomized to primary surgery alone, two studies revealed an increased frequency of patients who, after relapse, developed uncontrolled local disease even though relapse treatment often included radiotherapy (41,42). These studies illustrate the difficulty in achieving lasting local cure in cases of clinically manifest, locoregional recurrence.…”

Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy

“…In contrast, several randomized trials have reported low rates of clinically apparent internal mammary recurrence even in the absence of radiotherapy. 36,[75][76][77] The effect of internal mammary treatment on survival is unclear. Two randomized trials performed before the era of adjuvant systemic therapy showed no survival difference when internal mammary dissection was performed in addition to radical mastectomy.…”

“…19 The majority of the trials included pre-and postmenopausal women with node-positive disease who underwent modified radical mastectomy. [5][6][7][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] The adjuvant chemotherapy regimen most commonly used was cyclophosphamide, methotrexate and fluorouracil (CMF). The median duration of follow-up was 7.5-14.5 years.…”