The Total Synthesis of Heraclemycin B through β‐Ketosulfoxide and Aldehyde Annulation

Abstract

Herein we describe at otal synthesis of the natural product heraclemycin B. This synthetic approach follows aD iels-Alders trategy to form the anthracenone core fol-lowed by a b-ketosulfoxide and aldehydea nnulation to form the 4-pyranone Dring. The spectrald ata fort he synthesized product matches that reported in the isolation studies. Figure 1. Naturalp roducts heraclemycins A-D.

Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252

“…A concentrated cluster with nodes attributed to subfractions 1–7 was spotted within the whole molecular network ( Figure 2 a). Combining LC-MS-UV analysis and the MarinLit database retrieval ( , 15 June 2021) using the m / z values of 389.067 and 425.124 suggested the reasonable candidate molecules heraclemycin B [ 8 ] and bleomycin B [ 9 ]. Further analysis of the related molecular cluster indicated a series of putative new saliniquinone-related analogues through MarinLit database and SciFinder searches.…”