The Toxic Effect of Indoxacarb Exposure on Some Hematological and Hormonal Indices and Evaluating the Potential Alleviative Effects of Vitamin C and Zinc in Male Albino Rats

Abstract

The world is facing very severe disasters, most notably the toxic effects of pesticides on living organisms' health and the environment, whether directly or indirectly and in the short or long term. Some developing countries suffer from severe shortcomings regarding the necessary precautions to reduce the potential toxicity risks from handling or exposure to pesticides. This work achieved to study the toxic effect of sub-lethal dose of indoxacarb (100 mg/kg) exposure and evaluate the protective effects of vitamin C (200 mg/kg) and zinc (Zn) (100 mg/kg) (separately or together) in male albino rats. The experimental rats were randomly divided into five groups (n=6): control group, indoxacarbtreated group, indoxacarb+vitamin C-treated group, indoxacarb+Zn-treated group, and indoxacarb+vitamin C+Zn-treated group. All groups received orally the tested doses every 48 h for 21 days. The results indicated that indoxacarb induced significant changes of some hematological parameters (red blood cells (RBC) counts, white blood cells (WBC) counts, hemoglobin (Hb) content, hematocrit (Hct) value, mean corpuscular volume (MCV) and platelets counts) besides substantial alterations in the thyroid hormones (triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH)) and the sex hormones (total and free testosterone, progesterone, and estradiol). Furthermore, the administration of vitamin C and zinc together alleviated the alteration of later hematological and hormonal parameters in indoxacarbtreated rats. Conclusion: a mixture of vitamin C and zinc may show ameliorating effects against indoxacarb-toxicity through improving the examined biochemical parameters about the use of both alone.