The toxic influence and biodegradation of carbon nanofibers in freshwater invertebrates of the families Gammaridae, Ephemerellidae, and Chironomidae

Чайка, Владимир; Pikula, Konstantin; Vshivkova, Tatyana S.; Zakharenko, Alexander M.; Reva, Galina; Drozdov, K. A.; Vardavas, Alexander; Stivaktakis, Polychronis; Νikolouzakis, Τaxiarchis Κonstantinos; Stratidakis, Antonios; Kokkinakis, Manolis; Kalogeraki, Alexandra; Burykina, Tatyana I.; Sarigiannis, Dimosthenis; Холодов, А. С.; Golokhvast, Kirill S.

doi:10.1016/j.toxrep.2020.07.011

Cited by 12 publications

(4 citation statements)

References 51 publications

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“…The uptake of ENMs has rarely been studied in detail in C. riparius, and in the incidence when it has been (i.e., for fullerenes), particles were not seen to be taken up into tissues but remained in the lumen of the gut. 34 However, carbon nanofibers were observed to enter the intestinal cells of related Diamesa chironomid larvae, 84 suggesting that the ability of ENMs to cross the barrier of the gut lumen and into tissues may be materialspecific. In the better-studied aquatic invertebrate Daphnia magna, fullerenes have also not been observed to be taken up into tissues, again remaining in the gut lumen, 79 while Ag nanoparticles, 80 Au nanoparticles, 81 carbon nanotubes, 82 and GaInP nanowires 83 have been observed to be taken up.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Protein Fe–S Centers as a Molecular Target of Toxicity of a Complex Transition Metal Oxide Nanomaterial with Downstream Impacts on Metabolism and Growth

Niemuth

Zhang

Mohaimani

et al. 2020

Environ. Sci. Technol.

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Oxidative stress is frequently identified as a mechanism of toxicity of nanomaterials. However, rarely have the specific underlying molecular targets responsible for these impacts been identified. We previously demonstrated significant negative impacts of transition metal oxide (TMO) lithium-ion battery cathode nanomaterial, lithium cobalt oxide (LCO), on the growth, development, hemoglobin, and heme synthesis gene expression in the larvae of a model sediment invertebrate Chironomus riparius. Here, we propose that alteration of the Fe−S protein function by LCO is a molecular initiating event leading to these changes. A 10 mg/L LCO exposure causes significant oxidation of the aconitase 4Fe−4S center after 7 d as determined from the electron paramagnetic resonance spectroscopy measurements of intact larvae and a significant reduction in the aconitase activity of larval protein after 48 h (p < 0.05). Next-generation RNA sequencing identified significant changes in the expression of genes involved in 4Fe−4S center binding, Fe−S center synthesis, iron ion binding, and metabolism for 10 mg/L LCO at 48 h (FDR-adjusted, p < 0.1). We propose an adverse outcome pathway, where the oxidation of metabolic and regulatory Fe−S centers of proteins by LCO disrupts metabolic homeostasis, which negatively impacts the growth and development, a mechanism that may apply for these conserved proteins across species and for other TMO nanomaterials.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Protein Fe–S Centers as a Molecular Target of Toxicity of a Complex Transition Metal Oxide Nanomaterial with Downstream Impacts on Metabolism and Growth

Niemuth

Zhang

Mohaimani

et al. 2020

Environ. Sci. Technol.

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“…Therefore it does not represent a barrier for nanoparticles [44]. It was shown that nanosized particles are capable of entering midgut digestive cells [45]. These properties of the midgut makes it the most susceptible to the harmful effect of ingested toxins, as was shown in previous studies [32,33].…”

Section: Discussionmentioning

confidence: 83%

Histopathology of Chironomus riparius (Diptera, Chironomidae) exposed to metal oxide nanoparticles

Stojanović

Milošević

Vitorovic

et al. 2021

ARCH BIOL SCI BELGRA

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As the production of metal-based nanomaterials increases, it is inevitable that nano-scale products and byproducts will enter the aquatic environment. In terms of global production, the most abundant nano-oxides are TiO2, CeO2 and Fe3O4 nanoparticles. Chironomus riparius is commonly used for ecotoxicological assessment and defining its histopathological biomarkers that showcase the toxic effect of tested nanoparticles should lead to a better understanding of the consequences of nanomaterial accumulation in aquatic ecosystems. In this study, a histological description of the digestive and excretory systems as well as the fat body structure of C. riparius larvae is provided. In addition, potential histological biomarkers of nano-oxide toxicity were determined based on the obtained histopathological alterations in organs. Vacuolization was observed in epithelial cells of midgut region I that were treated with nano-Fe3O4 as well as in Malpighian tubules treated with nano-Fe3O4 and nano-CeO2. Larvae exposed to nano-TiO2 showed alterations in the fat body and midgut region II tissue architecture. Additionally, shortening of the intestinal brush border was determined in groups exposed to nano-Fe3O4. These results reveal the high sensitivity of these organs, which can be used as biomarkers in histopathological assessment and therefore lead to further improvement of existing methodology in ecotoxicological studies.

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“…Members of the Chironomidae can be used for minimum PMI estimation as well and are of special interest in the case of cadavers from aquatic environments [ 85 , 86 , 87 ]. The Antarctic midge has a set of core clock genes that are expressed on its head, including clock , period , timeless and vrille [ 88 ].…”

Section: Post-mortem Interval Determination By Biological Rhythms In ...mentioning

confidence: 99%

Common Ground between Biological Rhythms and Forensics

Janjić

Reisinger

Kanz

2022

Biology

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Biological clocks set the timing for a large number of essential processes in the living human organism. After death, scientific evidence is required in forensic investigations in order to collect as much information as possible on the death circumstances and personal identifiers of the deceased victim. We summarize the associations between the molecular mechanisms of biological rhythms and forensically relevant aspects, including post-mortem interval and cause of death, entomological findings, sex, age, ethnicity and development. Given their importance during lifetime, biological rhythms could be potential tools to draw conclusions on the death circumstances and the identity of a deceased person by mechanistic investigations of the different biological clocks in a forensic context. This review puts the known effects of biological rhythms on the functions of the human organism in context with potential applications in forensic fields of interest, such as personal identification, entomology as well as the determination of the post-mortem interval and cause of death.

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The toxic influence and biodegradation of carbon nanofibers in freshwater invertebrates of the families Gammaridae, Ephemerellidae, and Chironomidae

Abstract: Graphical abstract

Cited by 12 publications

References 51 publications

Protein Fe–S Centers as a Molecular Target of Toxicity of a Complex Transition Metal Oxide Nanomaterial with Downstream Impacts on Metabolism and Growth

Protein Fe–S Centers as a Molecular Target of Toxicity of a Complex Transition Metal Oxide Nanomaterial with Downstream Impacts on Metabolism and Growth

Histopathology of Chironomus riparius (Diptera, Chironomidae) exposed to metal oxide nanoparticles

Common Ground between Biological Rhythms and Forensics

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